Personalization of pharmacotherapy with sirolimus based on volumetric absorptive microsampling (VAMS) in pediatric renal transplant recipients-from LC-MS/MS method validation to clinical application.

Background: The benefits of pharmacotherapy with sirolimus (SIR) in pediatric transplant recipients are well established. Traditionally, whole blood samples have been used to measure SIR concentrations. Volumetric Absorptive Microsampling (VAMS) is an alternative sampling strategy suitable for Therapeutic Drug Monitoring (TDM).

Evaluation of ballistics euthanasia applied to stranded cetaceans using ethological and post-mortem computed tomography assessment.

Debilitated stranded cetaceans with low survival likelihood, may require euthanasia to avoid further suffering. Euthanasia can involve chemical or physical methods, including ballistics. Ballistics should cause instantaneous, permanent insensibility through brainstem disruption.

Assessment of Dried Serum Spots (DSS) and Volumetric-Absorptive Microsampling (VAMS) Techniques in Therapeutic Drug Monitoring of (Val)Ganciclovir-Comparative Study in Analytical and Clinical Practice.

Ganciclovir (GCV) and its prodrug valganciclovir (VGCV) are antiviral medications primarily used to treat infections caused by cytomegalovirus (CMV), particularly in immunocompromised individuals such as solid organ transplant (SOT) recipients. Therapy with GCV is associated with significant side effects, including bone marrow suppression. Therefore, therapeutic drug monitoring (TDM) is mandatory for an appropriate balance between subtherapeutic and toxic drug levels.

Illustrated cross-sectional computed tomography of the cetacean abdomino-pelvic organs.

Background: Computed tomography (CT) is a non-invasive diagnostic imaging modality which can be used to study the anatomy and morphology of live or deceased animals in-situ. In cetaceans, existing CT anatomy studies mostly focused on the head and thoracic regions. Using postmortem CT (PMCT) scans of Indo-Pacific finless porpoises (Neophocaena phocaenoides), this study describes the cross-sectional imaging anatomy of the cetacean abdomino-pelvic organs for the first time.