Publications by authors named "B Kopecky"
Article Synopsis
- The study investigates the link between inflammation and tissue fibrosis in human cardiac diseases, revealing unique fibroblast populations that contribute to heart dysfunction.
- Researchers used advanced techniques on heart samples to uncover these fibroblast types and their relationship with immune cells, specifically CCR2 macrophages, in promoting fibrosis through IL-1β signaling.
- By blocking IL-1β signaling, the study demonstrated reduced fibrosis and improved heart function, suggesting that targeting inflammation could be a promising approach for treating cardiac fibrosis.
Myocardial infarction initiates cardiac remodeling and is central to heart failure pathogenesis. Following myocardial ischemia-reperfusion injury, monocytes enter the heart and differentiate into diverse subpopulations of macrophages. Here we show that deletion of Hif1α, a hypoxia response transcription factor, in resident cardiac macrophages led to increased remodeling and overrepresentation of macrophages expressing arginase 1 (Arg1).
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- Tissue-resident macrophages play a complementary role to proinflammatory macrophages in driving atherosclerosis progression, making their detection and dynamic tracking crucial for understanding this disease.
- The study aimed to create a targeted PET radiotracer, [Cu]Cu-ICT-01, to specifically image CD163-positive macrophages in mouse models of atherosclerosis and evaluate its potential as a biomarker in humans.
- Results showed [Cu]Cu-ICT-01 had high binding affinity to CD163+ cells, demonstrated rapid clearance from blood and organs, and effectively detected CD163+ macrophages in various atherosclerosis models, confirming its specificity and functionality for tracking disease progression.