Effects of capsulorhexis size and position on post-surgical IOL alignment.

In cataract surgery, post-surgical stability of the intraocular lens plays a major role. This study aims to explore how the size and decentration of the capsulorhexis affect intraocular lens decentration and tilt by using numerical methods. Finite element models included zonules, ciliary body, capsular bag, and an IOL with two open-loop haptics were built.

Generating synthetic clinical text with local large language models to identify misdiagnosed limb fractures in radiology reports.

Large language models (LLMs) demonstrate impressive capabilities in generating human-like content and have much potential to improve the performance and efficiency of healthcare. An important application of LLMs is to generate synthetic clinical reports that could alleviate the burden of annotating and collecting real-world data in training AI models. Meanwhile, there could be concerns and limitations in using commercial LLMs to handle sensitive clinical data.

A wearable gait lab powered by sensor-driven digital twins for quantitative biomechanical analysis post-stroke.

Commonly, quantitative gait analysis post-stroke is performed in fully equipped laboratories housing costly technologies for quantitative evaluation of a patient's movement capacity. Combining such technologies with an electromyography (EMG)-driven musculoskeletal model can estimate muscle force properties non-invasively, offering clinicians insights into motor impairment mechanisms. However, lab-constrained areas and time-demanding sensor setup and data processing limit the practicality of these technologies in routine clinical care.

Molecular Tumor Board of the University Medical Center Groningen (UMCG-MTB): outcome of patients with rare or complex mutational profiles receiving MTB-advised targeted therapy.

Purpose: Molecular tumor boards (MTBs) are considered beneficial for treatment decision making for patients with cancer with uncommon, rare, or complex mutational profiles. The lack of international MTB guidelines results in significant variation in practices and recommendations. Therefore, periodic follow-up is necessary to assess and govern MTB functioning.