Publications by authors named "B Kofler"
Article Synopsis
- Glioblastoma (GBM) is the deadliest brain tumor in adults, and current therapies are largely ineffective, which drives the need for new treatment strategies based on the tumor's metabolic needs, specifically glucose and glutamine.
- A ketogenic metabolic therapy (KMT) approach targets these metabolic pathways by combining dietary changes with specific drugs to limit glycolysis and glutaminolysis, while promoting the use of non-fermentable fuels like ketones and fatty acids.
- The glucose-ketone index (GKI) serves as a biomarker to monitor treatment effectiveness, aiming to create a more hostile environment for tumor growth and improve outcomes in GBM as well as potentially other cancer types reliant on similar metabolic pathways.
Overcoming immunosuppression in cancer: how ketogenic diets boost immune checkpoint blockade.
Cancer Immunol Immunother
November 2024
Immune checkpoint blockade (ICB) is now part of the standard of care in the treatment of many forms of cancer, yet it lacks efficacy in some patients, necessitating adjunct therapies to support the anti-tumor immune response. Ketogenic diets (KDs), i.e.
View Article and Find Full Text PDFBackground: AMP-activated protein kinase (AMPK) is an evolutionarily conserved regulator of energy metabolism. AMPK is sensitive to acute perturbations to cellular energy status and leverages fundamental bioenergetic pathways to maintain cellular homeostasis. AMPK is a heterotrimer comprised of αβγ-subunits that in humans are encoded by seven individual genes (isoforms α1, α2, β1, β2, γ1, γ2 and γ3), permitting formation of at least 12 different complexes with personalised biochemical fingerprints and tissue expression patterns.
View Article and Find Full Text PDFUltrasound visualization of augmentation rhinoplasty using diced cartilage framework: A pictorial study.
J Plast Reconstr Aesthet Surg
October 2024
Article Synopsis
- Diced cartilage (DC) is important in rhinoplasty for creating a framework used in nasal dorsal augmentation, and two methods of applying DC were tested in 15 patients.
- Postoperative ultrasounds showed that all patients had detectable DC, with a notable reduction in perifocal edema over the year, while the grafts remained intact and did not migrate.
- High-resolution ultrasound and color Doppler imaging proved effective for visualizing DC and detecting new blood vessel formation in the grafts post-surgery.
Previously, we showed that restrictive diets, including ketogenic diet (KD), have an anti-inflammatory impact on the healthy gastrointestinal tract of mice. Afterward, we found that energy-restricting diets mitigate inflammation in the dextran sodium sulfate (DSS) colitis mouse model. The current study aimed to verify the impact of KD on DSS colitis and assess if the diet's fat composition influences the outcomes of the intervention.
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