Publications by authors named "B Knoppke"
Background: The development of graft fibrosis after pediatric liver transplantation (PLT) remains a major concern as it can lead to graft failure and ultimately graft loss. Elastography is a non-invasive method to assess liver fibrosis, but its role in the posttransplant setting is unclear. The aim of our study was to evaluate shear wave elastography (SWE) in the assessment of liver fibrosis after PLT, including split-liver recipients.
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- Pediatric liver transplantations can sometimes require retransplantation (reLT) due to complications like graft failure, with 31 out of 208 patients needing this procedure between 2008 and 2021.
- The study found that the main reasons for reLT included acute/chronic graft failure and complications like hepatic artery thrombosis, with a higher survival rate for patients undergoing multiple reLTs.
- Successful outcomes are achievable in specialized centers, emphasizing the importance of careful selection and preoperative preparation for patients undergoing liver retransplantation.
Article Synopsis
- Wolcott-Rallison syndrome is a rare genetic disorder characterized by neonatal diabetes and various health complications, including liver impairment and growth issues, with a significant impact on patient survival rates.
- A review of 62 studies involving 159 patients revealed a median age of presentation at 2.5 months and an average age of death at 36 months, with liver failure being a primary cause of mortality in some cases.
- Transplantation, especially liver or multi-organ transplants, notably improves survival outcomes, with better prognosis linked to specific genetic mutations (missense mutations).
Article Synopsis
- - Pediatric acute liver failure (PALF) is a serious condition with up to 50% of cases remaining unexplained, hindering effective treatment options like liver transplantation.
- - In a study involving 260 children from 19 countries, whole-exome sequencing (WES) identified genetic causes in 37% of indeterminate PALF cases, with a particularly high diagnostic rate in infants and those with recurrent liver failure.
- - The research uncovered 36 distinct genes associated with PALF, highlighting mitochondrial diseases as the most common cause and underscoring the need for advanced genetic testing in diagnosing and treating this condition.
Background: After pediatric split liver transplantation, intra-abdominal loss of domain due to large-for-size left lateral grafts is a frequent problem for fascial closure and potentially leads to reduced liver perfusion and abdominal compartment syndrome. Therefore, delayed fascial closure with the use of temporary silastic meshes and reoperation or alternative fascial bridging procedures are necessary.
Methods: Between March 2019 and October 2021, biologic meshes were used for abdominal wall expansion in 6 cases of pediatric split liver transplantation.