Publications by authors named "B Knebel"
Aims: We examined the association of the G allele in the single-nucleotide polymorphism (SNP) rs738409 in the third exon of patatin-like phospholipase domain-containing 3 gene (PNPLA3) gene, with chronic kidney disease in diabetes endotypes.
Methods: Participants with recent-onset diabetes (n = 707) from the prospective German Diabetes Study (GDS) underwent cluster assignment, detailed phenotyping, genotyping and magnetic resonance spectroscopy to quantify hepatocellular lipid content (HCL).
Results: Severe insulin-resistant diabetes (SIRD) had the lowest glomerular filtration rates (eGFR) and highest HCL compared to severe insulin-deficient, moderate obesity-related, moderate age-related and severe autoimmune diabetes endotypes (all p < 0.
Article Synopsis
- * Results show that four specific single nucleotide polymorphisms (SNPs) in individuals with type 2 diabetes are linked to DSPN, meaning those with certain genetic variations are more likely to experience nerve damage, especially as the criteria for diagnosis become stricter.
- * The findings support the idea that genetic factors related to the metabolism of glucose intermediates play a significant role in the development of diabetic neuropathy, highlighting potential areas for
Article Synopsis
- * In a study with mice, chronic stress made them use less energy and gain weight, even though they ate more food.
- * After the stress, their liver cells lost the ability to respond to changes in energy, and there were changes in how their DNA was organized, which might affect how their energy works in the future.
Background And Aims: Increased hepatocellular lipid content (HCL) is linked to insulin resistance, risk of type 2 diabetes and related complications. Conversely, a single-nucleotide polymorphism (TM6SF2; rs58542926) in the transmembrane 6 superfamily member 2-gene has been associated with nonalcoholic fatty liver disease (NAFLD), but lower cardiovascular risk. This case-control study tested the role of this polymorphism for tissue-specific insulin sensitivity during early course of diabetes.
View Article and Find Full Text PDFEpisodes of chronic stress can result in psychic disorders like post-traumatic stress disorder, but also promote the development of metabolic syndrome and type 2 diabetes. We hypothesize that muscle, as main regulator of whole-body energy expenditure, is a central target of acute and adaptive molecular effects of stress in this context. Here, we investigate the immediate effect of a stress period on energy metabolism in Musculus gastrocnemius in our established C57BL/6 chronic variable stress (Cvs) mouse model.
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