Solid dispersion of ketoprofen in pellets.

The formulation of ternary solid dispersions of ketoprofen with Macrogol and kollagen hydrolizate derivative as carriers was elaborated on the basis of the results of the experiments in which different methods of solid dispersion preparation (melting, solvent method, different cooling), different concentrations of drug/carriers and molecular weight of Macrogol were tested. The best solid dispersion consisted of: ketoprofen-Macrogol 6000-KLH(T) (1+8. 9+0.

[In vitro assessment of metronidazole adapted to the treatment of periodontopathies].

Chemical and biological assessment was done in vitro of a form of metronidazole for application into deep pouches in periodontal diseases. The obtained plates with metronidazole contained 1.4 mg (37%) of pure substance.

In vitro study of (2S, 2'S) N,N'-dimethyl-N, N'-bis [1(3', 4', 5'-trimethoxybenzoyloxy) butyl-2] ethylenediamine salts and their bioavailability.

The aim of this study was to improve the oral dosage form of the title compound. The study include base, dihydrochloride and dimaleate. In vitro study was carried out on rat intestine, in vivo on rats and rabbits.