Publications by authors named "B Kimmel"
Article Synopsis
- Cancer patients often face harsh side effects from traditional treatments like chemotherapy and radiotherapy, leading to a push for more targeted therapies.
- Engineered immunotherapies show promise for better targeting and prevention of tumor growth, but issues like ineffective activation and unwanted side effects still need to be addressed.
- Prodrug therapies, which are activated selectively, could overcome these challenges by using advanced bioconjugation techniques for safer and more controlled delivery of immunotherapeutics.
Purpose: This study aimed to describe stroke survivors' experiences receiving telemedicine visits at the Lone Star Stroke Consortium during the COVID-19 pandemic.
Materials And Methods: A qualitative descriptive phenomenological design was applied to gather patients' telemedicine experiences through in-depth interviews, using a study guide. Audio-recorded interviews were conducted via ZOOM and transcribed verbatim.
Article Synopsis
- - The STING pathway plays a crucial role in activating anti-tumor immunity, leading to interest in developing STING agonists for cancer treatment, but their effectiveness is limited by drug delivery issues.
- - Researchers created a new drug delivery system called SAPCon that combines a STING-activating prodrug with a polymer to enhance the drug's circulation and ensure it accumulates in tumors effectively.
- - Testing showed that SAPCon significantly boosts immune responses in tumors, leading to slower tumor growth and better survival rates in breast cancer models, thereby highlighting its potential as a powerful tool in cancer immunotherapy.
The blood-brain barrier (BBB) is a highly selective network of various cell types that acts as a filter between the blood and the brain parenchyma. Because of this, the BBB remains a major obstacle for drug delivery to the central nervous system (CNS). In recent years, there has been a focus on developing various modifiable platforms, such as monoclonal antibodies (mAbs), nanobodies (Nbs), peptides, and nanoparticles, as both therapeutic agents and carriers for targeted drug delivery to treat brain cancers and diseases.
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