Nanoconfinement-induced shift in photooxidative degradation pathway of polystyrene.

Polymer nanocomposites with high concentrations of nanoparticles (NPs) possess exceptional mechanical, transport, and thermal properties. To enable their widespread use in structural applications and functional coatings, it is crucial to understand how nanoconfinement and the polymer-NP interface influence polymer degradation under various environmental conditions, including prolonged UV exposure. In this study, we investigate the photooxidative degradation of polystyrene (PS)-confined in the interstices of SiO NP films.

Phase II randomized study of dostarlimab alone or with bevacizumab versus non-platinum chemotherapy in recurrent gynecological clear cell carcinoma (DOVE/APGOT-OV7/ENGOT-ov80).

Background: Recurrent gynecological clear cell carcinoma (rGCCC) has a low objective response rate (ORR) to chemotherapy. Previous preclinical and clinical data suggest a potential synergy between immune checkpoint inhibitors and bevacizumab in rGCCC. Dostarlimab, a humanized monoclonal antibody targeting programmed cell death protein 1 (PD-1), combined with the anti-angiogenic bevacizumab, presents a novel therapeutic approach.

Postoperative Urinary Complications in Minimally Invasive vs. Abdominal Radical Hysterectomy: A Meta-Analysis with a Focus on Ureterovaginal Fistula.

Objective: This study aims to perform a systematic review and meta-analysis to compare the incidence of specific postoperative urologic complications, such as vesicovaginal fistula and ureterovaginal fistula, in patients undergoing minimally invasive radical hysterectomy (MIRH) versus abdominal radical hysterectomy (ARH) for early-stage cervical cancer.

Data Sources: A comprehensive literature search was conducted in PubMed, the Cochrane Library, Web of Science, ScienceDirect, and Google Scholar up to April 2024.

Method: Comparative studies evaluating postoperative urologic complications following MIRH and ARH were included.

Association between chronic ambient heavy metal exposure and mental health in Korean adult patients with asthma and the general population.

Background: Insufficient evidence is available to confirm the effect of exposure to airborne metals on mental disorders, particularly among asthmatics. We aimed to investigate the effect of airborne metal exposure on mental health responses in asthmatics and the general population.

Methods: Using nationally representative cross-sectional data, a total of 47,796 adults were analyzed.

Experimental horizontal transfer of phage-derived genes to Drosophila confers innate immunity to parasitoids.

Metazoan parasites have played a major role in shaping innate immunity in animals. Insect hosts and parasitoid wasps are excellent models for illuminating how animal innate immune systems have evolved to neutralize these enemies. One such strategy relies on symbioses between insects and intracellular bacteria that express phage-encoded toxins.