Publications by authors named "B Kern"
Academic health sciences libraries ("libraries") offer services that span the entire research lifecycle, positioning them as natural partners in advancing clinical and translational science. Many libraries enjoy active and productive collaborations with Clinical and Translational Science Award (CTSA) Program hubs and other translational initiatives like the IDeA Clinical & Translational Research Network. This article explores areas of potential partnership between libraries and Translational Science Hubs (TSH), highlighting areas where libraries can support the CTSA Program's five functional areas outlined in the Notice of Funding Opportunity.
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- - Most US children and adolescents fall short of recommended daily physical activity (PA), and schools could play a crucial role in providing more access to physical education (PE) and recreational opportunities throughout the day.
- - A study involving 4,845 K-12 PE teachers across 25 states found that access to PE and PA is generally better in elementary schools compared to middle and high schools, revealing a gap with national recommendations.
- - There's a clear need for states to improve access to PE and recreational activities to align more closely with national guidelines, emphasizing the importance of collaboration among educators, policymakers, and community stakeholders to ensure equitable access for all students.
Background And Aims: In contrast to extensively studied hypercholesterolemia, knowledge of hypocholesterolemia is limited. This study aims to assess the prevalence, clinical characteristics, and genetics of children and adolescents with hypocholesterolemia.
Methods: This national prospective cross-sectional cohort study was part of Slovenia's universal opt-out cholesterol screening program.
Background: Respiratory tract infections (RTIs) drive lung function decline in children with cystic fibrosis (CF). While the respiratory microbiota is clearly associated with RTI pathogenesis in infants without CF, data on infants with CF is scarce. We compared nasal microbiota development between infants with CF and controls and assessed associations between early-life nasal microbiota, RTIs, and antibiotic treatment in infants with CF.
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- Uncontrolled regeneration in the intestinal epithelium can lead to cancer, highlighting the need for precise regulation during tissue renewal.
- Researchers discovered that activating the liver X receptor (LXR) pathway helps balance intestinal regeneration and tumor growth after damage.
- LXR activation enhances regeneration by producing amphiregulin and is crucial for controlling tumor growth, with diminished LXR-related activity found in human colorectal cancer samples.