Levels of some cytokines in subretinal fluid in proliferative vitreoretinopathy and rhegmatogenous retinal detachment.

Purpose: To determine the cytokine-mediated pathways of inflammation in the clinical course of proliferative vitreoretinopathy (PVR).

Methods: Cytokines IL-2, IL-6, INF-gamma were measured by enzyme-linked immunosorbent assays. Aspirates of subretinal fluid were obtained from 14 eyes with PVR and six with uncomplicated rhegmatogenous retinal detachments.

Adjuvant activity of the Escherichia coli WF table L-form cytoplasmic membranes.

It was established that the stable E. coli WF+ L-form cytoplasmic membranes (CM) increase the antibody response in rabbit during experimental hyperimmunization with cells of Streptococcus pyogenes A49 and Proteus mirabilis D52. Using the skin-induration test and the reaction for aggregation of macrophages in presence of homologous antigens it was established that CM increase the cell-mediated immunity of guinea-pigs to protein antigens of the same bacterial strains.

Effect of oxadiarrhot on some mechanisms of the immune system.

The preliminary application of the preparation Oxadiarrhot has no effect on the progress and the result of bacterial and mixed (bacterial-viral) infections. In animals treated with the preparation antigen-reactive and antibody-productive cells show insignificant decrease in number. There is no essential influence of the preparation on the mononuclear phagocytes system--the alveolar macrophages and polymorphonuclears do not change their functions.

Immunomodulating activity of ginsenoside Rg1 from Panax ginseng.

The immunomodulatory activity of ginsenoside Rg1 from Panax ginseng was studied in mice using sheep red cells as the antigen. It was found that ginsenoside Rg1 at a dose of 10 mg/kg administered for three consecutive days before immunization increased the number of spleen plaque-forming cell, the titers of sera hemagglutinins as well as the number of antigen-reactive T-cells. Ginsenoside Rg1 also increased the number of T-helper cells with respect to the whole T-cell number and the splenocyte natural killer activity.