Publications by authors named "B Keikhaei"
Hematologic Parameters Cut-off Assessment of Adult Alpha-Thalassemia Patients in Iran.
Int J Hematol Oncol Stem Cell Res
October 2024
Thalassemia is one of the most common blood disorders in Iran. Alpha-thalassemia is caused by the deletion of the alpha-globin gene. The frequency of deletions in the alpha-globin gene is associated with microcytosis and hypochromia, making hematological parameters valuable predictive tools in the initial identification of alpha-thalassemia patients.
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- Gaucher's disease is a rare autosomal recessive disorder caused by a mutation in the glucocerebrosidase gene, with common symptoms including organ enlargement and neurological issues, but can present atypically, leading to delayed diagnosis.
- Two adult cases (a 44-year-old man with chronic cough and a 27-year-old woman with itching) are discussed, and despite treatment for their symptoms, significant improvement only occurred after diagnosing Gaucher's disease through sonography and bone marrow tests, identifying specific mutations in the GBA1 gene.
- The report emphasizes the need for awareness of rare symptom presentations in Gaucher's disease, particularly in populations with high rates of consanguinity, to facilitate earlier diagnosis and treatment.
Article Synopsis
- Immune thrombocytopenia (ITP) is an autoimmune disorder leading to low platelet counts due to increased destruction and insufficient production of platelets.
- Research is indicating that the gut microbiome differs between ITP patients and healthy individuals, potentially influencing platelet counts and treatment responses.
- While these findings suggest the microbiome may help with diagnosis and treatment personalization, the lack of consistent results means more studies are necessary to clarify its role in ITP.
Background: Type 3 von Willebrand disease (VWD) is the most severe form of this disease owing to the almost complete deficiency of von Willebrand factor (VWF). Replacement therapy with plasma-derived products containing VWF or recombinant VWF rarely cause the development of alloantibodies against VWF that may be accompanied by anaphylactic reactions.
Objective: The objective of this study was to assess the prevalence of anti-VWF alloantibodies in subjects with type 3 VWD enrolled in the 3WINTERS-IPS.
In this study, we describe a new missense variant on the β-globin gene in a heterozygous form in a female individual. Standard methods were used to determine red blood cell indices and perform hemoglobin analyses. Molecular studies were performed on the genomic DNA isolated from peripheral blood cells.
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