Publications by authors named "B Kazemi"
Leishmaniasis is a parasitic disease that is commonly found in tropical and sub-tropical regions. Currently, there is no protective antileishmanial vaccine, and the available clinical drugs have serious side effects. On the other hand, due to the emergence of multidrug-resistant strains of the causative pathogens, the study and design of novel antileishmanial agents is urgently needed.
View Article and Find Full Text PDFImmunogenic Consideration of a Designed Polypeptide Against Brucellosis Compared to RB51: An Study.
Avicenna J Med Biotechnol
January 2024
Background: Brucellosis in livestock and its transmission to humans through the consumption of contaminated dairy products is an important issue. The introduction of new approaches using immunogenic proteins against and diagnosing brucellosis is a serious issue in human health.
Methods: contains five proteins including: MOXR family ATPase-α2, T9SS C-terminal target domain-containing protein, Cobyric acid synthase, Hypothetical protein, and VirB11 type IV Secretion protein, which were considered and the designed recombinant polypeptide was produced and evaluated.
Article Synopsis
- Apoptin is a promising anticancer protein that selectively induces apoptosis in tumor cells, particularly in breast cancer lines, highlighting its potential for cancer therapy.
- Researchers successfully created two forms of apoptin fusion proteins (SUMO-PTD4-Apoptin and PTD4-Apoptin) and tested their effects on breast cancer cells (MDA-MB-231 and MCF-7) and normal cells (MCF-10A) using various assays.
- Results showed that SUMO-PTD4-Apoptin demonstrated a lower IC50 value in cancer cells than in normal cells, indicating higher cytotoxicity, while PTD4-Apoptin had similar effects across both cancer
Article Synopsis
- Intramedullary spinal cord metastasis (ISCM) is rare and typically found in advanced cancer patients, with no clear treatment protocols or consistent outcomes currently established.* -
- The case presented involves a 70-year-old woman with ovarian adenocarcinoma and upper thoracic spinal cord metastasis, highlighting a surgical management approach alongside literature review.* -
- The authors emphasize a multidisciplinary and personalized treatment strategy based on the patient's overall health, need for a definitive diagnosis, and the severity of systemic disease to improve quality of life and survival.*
The prevalence of kidney stone disease is increasing globally, with calcium oxalate stones being the most common type. Oxalyl-CoA decarboxylase (OXC), an enzyme produced by the gut bacterium Oxalobacter formigenes, plays a crucial role in oxalate metabolism. Deficiencies in OXC activity can lead to the accumulation of oxalate, contributing to kidney stone formation.
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