Publications by authors named "B Kawala"
Ankyloglossia is a congenital, abnormally short, thickened, or tight lingual frenulum that restricts tongue mobility, which may impair the development of the lower face morphology, namely the occlusion and skeleton. The aim of this study was to evaluate whether and how the lingual frenotomy benefits the occlusion and lower face skeleton development. The authors, independently and in duplication, performed searches of PubMed, Cochrane Library, Medline, Web of Science, and Embase, introducing the following keywords: tongue tie, ankyloglossia, and short lingual frenum/frenulum, combined with malocclusion, lower face skeleton, and hyoid bone.
View Article and Find Full Text PDFOrthodontic treatment involves moving teeth within the alveolar ridge. Bone remodeling is associated with the activity of osteoblasts and osteoclasts. Procedures such as corticotomy-assisted orthodontic therapy (CAOT) or periodontally accelerated osteogenic orthodontics (PAOO) are intended to reduce bone density and negative stress on the grip side and therefore limit bone resorption during orthodontic movement or add bone substitute material so that the tooth does not cross the vestibular plate.
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- Cleft lip and/or palate (CL/P) are the most common craniofacial congenital anomalies, influenced by both genetic and environmental factors.
- The study examined the relationship between four specific single nucleotide polymorphisms (SNPs) and CL/P in a Polish population, analyzing DNA from 209 affected individuals and 418 healthy controls.
- Significant associations were found, especially for SNP rs987525, where the AC genotype increased CL/P risk and the CC genotype decreased it; rs4714384 also showed a reduced risk with the CT genotype, while the other two SNPs did not have notable effects.
Article Synopsis
- - Orofacial clefts (OFCs) are the second most prevalent birth defect globally, caused by a mix of genetic and environmental factors.
- - The study analyzed the relationship between specific genetic variants (SNPs) and non-syndromic OFCs in a Polish sample of 209 affected individuals and 418 healthy controls.
- - A significant link was found between the rs7078 SNP and the likelihood of OFCs, while other SNPs (rs1081131, rs13041247, rs3769817) showed no significant correlation.
Article Synopsis
- Non-syndromic orofacial cleft (OFC) is a prevalent facial developmental defect, influenced by a mix of genetic and environmental factors, making it a complex issue globally.
- A study investigating specific single nucleotide polymorphisms (SNPs) in a Polish population found no significant associations for most SNPs tested but identified the rs1533767 variant with a notable increased risk for OFC.
- The research highlights that the rs1533767 polymorphism in the WNT gene is a crucial risk marker for developing OFC among the Polish individuals studied.