Publications by authors named "B Kasztelewicz"
Article Synopsis
- - A study was conducted among healthcare workers at a children's hospital to assess SARS-CoV-2 infection rates before and after a vaccination program, finding a 19.4% overall infection rate with 45.1% being asymptomatic individuals.
- - Nurses were at a higher risk of infection compared to physicians, with significant odds ratios showing their vulnerability before the vaccination program was implemented, which achieved 88.9% coverage among HCWs.
- - Post-vaccination, the infection rate dropped to 6.4%, with unvaccinated individuals showing a much higher rate (40%) compared to those with at least one vaccine dose (3.2%), indicating a high vaccine efficacy of 95% in fully vaccinated HCWs.*
Congenital cytomegalovirus infection (cCMV) is the most common intrauterine infection with central nervous system (CNS) involvement. There is limited data on the associations between Single Nucleotide Polymorphisms (SNPs) in genes involving the first-line defense mechanism and the risk of CNS damage during cCMV. We investigated the associations between neuroimaging findings and SNPs in genes encoding the following cytokines and cytokine receptors in 92 infants with cCMV: interleukins (IL1B rs16944, IL12B rs3212227, IL28B rs12979860), C-C motif chemokine ligand 2 (CCL2 rs1024611), dendritic cell-specific intercellular adhesion grabbing non-integrin (DC-SIGN rs735240), Toll-like receptors (TLR2 rs5743708, TLR4 rs4986791, TLR9 rs352140).
View Article and Find Full Text PDFThe Limitations of Cytomegalovirus DNA Detection in Cerebrospinal Fluid of Newborn Infants With Congenital CMV Infection: A Tertiary Care Neonatal Center Experience.
Pediatr Infect Dis J
September 2021
Background: Congenital cytomegalovirus (cCMV) infection of the central nervous system (CNS) can cause ventriculomegaly, gliosis, calcifications and cortical defects. Detection of CMV DNA in cerebrospinal fluid by PCR (CSF-CMV-PCR) is a marker of CNS involvement.
Objective: To evaluate a diagnostic value of the positive CSF-CMV-PCR in cCMV.
Data on the prevalence of the SARS-CoV-2 antibody in healthcare workers (HCWs) is scarce, especially in pediatric settings. The purpose of this study was to evaluate SARS-CoV-2 IgG-positivity among HCWs of a tertiary pediatric hospital. In addition, follow-up of the serological response in the subgroup of seropositive HCWs was analysed, to gain some insight on the persistence of IgG antibodies to SARS-CoV-2.
View Article and Find Full Text PDFBackground: There are limited data on factors that determine viral load (VL) in congenital cytomegalovirus (cCMV) infection. Single nucleotide polymorphisms (SNPs) might influence individual host response to infection. This study aimed to investigate the association between SNPs in genes encoding cytokines or cytokine receptors and VL in newborns with cCMV.
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