Gene expression profiles reveal an upregulation of E2F and downregulation of interferon targets by HPV18 but no changes between keratinocytes with integrated or episomal viral genomes.

Persistent infections with human papillomaviruses type 18 can result in the development of cervical cancer. HPV18 genomes persist extrachromosomally in low-grade and precancerous lesions but are always integrated in cervical cancers, and this might contribute to the progression of HPV18-induced lesions. To address whether integration induces additional changes in host cells, several keratinocyte lines with wild type and replication-deficient E1 mutant HPV18 (E1C-TTL) genomes were analyzed with high density oligonucleotide arrays.

Recent onset arthritis in the elderly: a 5 year longitudinal observational study.

Objective: To study the spectrum of diagnoses, course, and outcome of recent onset arthritis after the age of 60, presenting as rheumatoid arthritis (RA)-like disease.

Methods: A 5 year longitudinal observational study enrolled 92 consecutive patients (median age 73 yrs, 54/38 women/men, median duration of arthritis 12 weeks at inclusion).

Results: Forty-eight percent were classified as having RA according to the 1987 American Rheumatism Association criteria, 52% as non-RA (41.

Auranofin is safe and superior to placebo in elderly-onset rheumatoid arthritis.

The efficacy, toxicity and possible steroid-sparing properties of auranofin in the treatment of elderly-onset rheumatoid arthritis (EORA) were studied in a 2 yr prospective double-blind placebo-controlled clinical trial. Sixty-five patients with onset of arthritis after the age of 60 yr were randomized to either auranofin 3 mg b.i.

Acute sarcoid arthritis: occurrence, seasonal onset, clinical features and outcome.

In a 2-yr prospective follow-up study of patients presenting clinically with possible reactive arthritis (ReA), 17 (9%) of the patients turned out to have acute sarcoid arthritis (SA). The number of new cases of SA per year was 2.9/100,000 persons in the city of Oslo between 18 and 60 yr of age.

Reactive arthritis: a favorable 2 year course and outcome, independent of triggering agent and HLA-B27.

Objective: To study the 2 year course and clinical and radiological outcome of reactive arthritis and to identify possible outcome predictors.

Methods: Patients with chlamydia induced arthritis (n = 25) and arthritis induced by enterobacteria (n = 27), all derived from a 2-year epidemiological study on reactive arthritis (ReA) and possible ReA, were followed prospectively with clinical, laboratory and radiographic examinations.

Results: After one year, 40% of patients with chlamydia induced arthritis and 20% of those with enteroarthritis still had clinical signs of arthritis.