The determinants of serum vitamin D levels in participants in a melanoma case-control study living in a temperate climate.

Background: We report the determinants of serum levels of vitamin D in a U.K. melanoma case-control study benefitting from detailed exposure and genotyping data.

The determinants of periorbital skin ageing in participants of a melanoma case-control study in the U.K.

Background: Skin ageing is said to be caused by multiple factors. The relationship with sun exposure is of particular interest because the detrimental cutaneous effects of the sun may be a strong motivator to sun protection. We report a study of skin ageing in participants of an epidemiological study of melanoma.

Relationship between sun exposure and melanoma risk for tumours in different body sites in a large case-control study in a temperate climate.

Aim: A melanoma case-control study was conducted to elucidate the complex relationship between sun exposure and risk.

Methods: Nine hundred and sixty population-ascertained cases, 513 population and 174 sibling controls recruited in England provided detailed sun exposure and phenotype data; a subset provided serum 25-hydroxyvitamin D(2)+D(3) levels.

Results: Phenotypes associated with a tendency to sunburn and reported sunburn at ≥ 20 years of age were associated with increased melanoma risk (odds ratio (OR) 1.

Melanocytic nevi, nevus genes, and melanoma risk in a large case-control study in the United Kingdom.

Background: Increased number of melanocytic nevi is a potent melanoma risk factor. We have carried out a large population-based case-control study to explore the environmental and genetic determinants of nevi and the relationship with melanoma risk.

Methods: We report nevus phenotype in relation to differing patterns of sun exposure, inherited variation at loci shown in recent genome-wide association studies to be nevus genes, and risk.