Therapy-Induced Growth and Sexual Maturation in a Developmentally Infantile Adult Patient with a PROP1 Mutation.

Background: Hypopituitarism as a result of PROP1 (prophet of PIT1) mutation represents the most common genetic cause of combined deficiency of pituitary hormones and due to growth retardation it is typically diagnosed in childhood.

Case Description: We present a unique case report of a prepubertal woman with growth retardation in whom combined pituitary hormone deficiency [central hypopituitarism, hypogonadism, and growth hormone (GH) deficiency] caused by homozygous mutation c.150delA in the PROP1 gene was diagnosed late in young adulthood due to unfavorable life circumstances.

Vitamin D in anxiety and affective disorders.

Reduced levels of vitamin or its metabolites have been reported in various psychiatric disorders. Insufficient levels of vitamin D in depressive patients have been confirmed by many authors, but there have been conflicting results in subjects with anxiety disorders. In the present cross-sectional study, levels of calcidiol were determined in groups of depressive men and women and in men and women with anxiety disorders and compared with age matched controls.

[The transrectal ultrasonography of prostate in men with congenital hypogonadism treated by long term testosterone replacement therapy].

Background: The aim of the study was to evaluate prostate transrectal ultrasonography findings in men with congenital hypogonadism treated by long term testosterone replacement therapy.

Methods: We have gradually included 31 men with congenital hypogonadism in period of 2001-2011. The average follow-up was 7.

[Calcitriol endocrine microsystems - developmental aspects and prerequisites for their lifelong functionality].

New findings regarding the local synthesis of calcitriol, its binding on nuclear receptors and its regional tissue effects have led to discovery of its endocrine microsystems. Their application in growing organisms and their lifelong functionality provide possible preventive and treatment modalities in multiple ailments, mostly by natural and minimally expensive means.

[Growth hormone treatment in the Institute of Endocrinology].

Institute of Endocrinology became a pediatric center for growth hormone treatment in 1993, after the existing cohort of children treated in the Department of Pediatrics of the Postgraduate Medical School (IPVZ, FTN) had been transferred here. In 2004 it became also a center for adults. At the end of 2006 the total number of those, who underwent the treatment amounted to 408 patients.