Development and Dissolution Study of a β-Galactosidase Containing Drinking Straw.

Today, in addition to many different physicochemical and pharmacological properties of the active ingredients and excipients, the developer of a pharmaceutical formulation must take into account several factors during the formulation process in order for the patient to cooperate to use the formulation accurately. One of the innovative solutions in paediatrics may be the use of medicated drinking straws. For our studies, we successfully prepared lactase-containing, rapid disintegration particles by two techniques commonly used in the pharmaceutical industry.

Comparative Evaluation of Pellet Cushioning Agents by Various Imaging Techniques and Dissolution Studies.

Most of the commercially available pharmaceutical products for oral administration route are marketed in the tablet dosage forms. However, compression of multiparticulate systems is a challenge for the pharmaceutical research and industry, especially if the individual unit is a coated particle, as the release of the active ingredient depends on the integrity of the coating. In the present study, polymer-coated pellets tableted with different types of excipients (powder, granules, pellets) then were investigated by various tablet-destructive (microscopic) and tablet non-destructive (microfocus X-ray; microCT) imaging methods.

Development of laboratory-scale high-speed rotary devices for a potential pharmaceutical microfibre drug delivery platform.

The production of polymer microfibres and nanofibres using rotary jet spinning as platforms for drug delivery and tissue engineering applications has been explored. The aligned orientation of fibres and consequent improvement in the mechanical properties of the scaffold are essential in several pharmaceutical and biomedical applications, where elastic materials with high tensile resistance are required. This study aimed to develop high-speed rotary jet devices to fabricate polyvinylpyrrolidone-based homopolymer and copolymer rotary-spun fibres and establish a correlation between the operational parameters of the devices and the morphology and microstructure of the fabricated fibres.

Physicochemical analysis in the evaluation of reconstituted dry emulsion tablets.

The aim of this study was to characterize the formation of emulsions by droplet size analysis and turbidimetry during reconstitution from a solid dosage form, namely from dry emulsion systems, which carry an oil phase for poorly soluble active ingredients. For the dry emulsion systems tablets were prepared either from oil-in-water systems using a freeze-drying process or through direct compression containing the same oil and excipients. The ratios of oil to emulgents and oil to xanthan gum were equal in both methods.

Lubricant-Induced Crystallization of Itraconazole From Tablets Made of Electrospun Amorphous Solid Dispersion.

Investigation of downstream processing of nanofibrous amorphous solid dispersions to generate tablet formulation is in a quite early phase. Development of high speed electrospinning opened up the possibility to study tableting of electrospun solid dispersions (containing polyvinylpyrrolidone-vinyl acetate and itraconazole [ITR] in this case). This work was conducted to investigate the influence of excipients on dissolution properties and the feasibility of scaled-up rotary press tableting.