Publications by authors named "B Kaku"

Euglycemic diabetic ketoacidosis (eDKA) has emerged as an adverse event associated with sodium-glucose transporter-2 inhibitors (SGLT2i). We present two consecutive cases of SGLT2i-induced eDKA, both manifested as life-threatening coronary vasospastic angina (VSA). Case 1: A 64-year-old male overweight patient with type 2 diabetes (BMI 28.

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Kounis syndrome is an allergic acute coronary syndrome (ACS) characterised by coronary artery spasm, plaque erosion/rupture or stent thrombosis caused by mast cell and other interacting cell activation. Although intracoronary imaging modalities can detect those ACS mechanisms, Kounis syndrome due to plaque rupture has rarely been reported using intracoronary imaging. We present the case of a woman in her 70s who developed Kounis syndrome as a result of plaque rupture detected with optical coherence tomography (OCT).

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We experienced a case of acute multiple organ ischemia and multiple organ failure due to atypical aortic coarctation (AAC). Since the patient's hemodynamics were too unstable to perform surgical revascularization, we performed urgent endovascular therapy (EVT) with a stent. Eventually, the patient achieved remission from multiple organ failure and a satisfactory clinical outcome.

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Introduction: Familial hypercholesterolaemia (FH) is an autosomal-dominant inherited genetic disease. It carries an extremely high cardiovascular risk associated with significantly elevated low-density lipoprotein (LDL) cholesterol. The diagnostic rate of this disease in some European nations is quite high, due to the presence of multiple prospective registries.

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Article Synopsis
  • The study aimed to identify genetic variants causing cardiac conduction system disease (CCSD) in patients using whole-exome sequencing (WES) and evaluate the effectiveness of functional studies in determining pathogenicity.
  • Researchers conducted WES on 23 patients with early-onset CCSD and analyzed 117 genes associated with heart conditions, identifying five patients with pathogenic protein truncating variants and finding 21 additional variants of uncertain significance.
  • Functional analyses using zebrafish models demonstrated that certain genetic variants affected heart function, leading to a reclassification of some variants from uncertain to likely pathogenic in six patients, highlighting the potential of such studies in genetic research.
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