Anti-cystitis glandularis action exerted by glycyrrhetinic acid: bioinformatics analysis and molecular validation.

Cystitis glandularis (CG) is a chronic hyperplastic disorder of the bladder, and the available clinical drug therapy is insufficient currently. Glycyrrhetinic acid (GA), a bioactive compound extracted from the roots of Glycyrrhiza glabra, is found with beneficial actions, including anti-inflammatory and anti-oxidative effects. We previously reported that GA relieves CG symptoms in animal model, implying the potential application of GA to treat CG.

Straightening trajectory of hooked fibers in the fiber transport channel of rotor spinning investigated by fluid solid coupled simulation.

The airflow in the transport channel contributes to the accelerated straightening of the hooked fibers, which greatly influences the structural properties of the yarn. To study the straightening process of hooked fiber in the fiber transport channel, Altair EDEM 2022 software was used to establish flexible fiber models, and combined with ANSYS Fluent 2022R1 simulation software, the fluid-solid coupling method was used to simulate the air velocity distribution in the fiber transport channel and the straightening process of the hooked fibers in the airflow field. The numerical simulated air flow is verified by Hagen-Poissuille pipe flow equation.

Formal Transesterification Reaction of But-3-enyl Esters Enabled by a Synergistic Nickel/Zinc Relay.

The transition metal-catalyzed coupling reaction has renewed the role of ester as an electrophilic partner. In this context, we describe a synergistic Ni/Zn-catalyzed formal transesterification reaction of but-3-enyl esters with tetrahydrofuran and alkyl iodides to give 4-alkoxylbutyl esters. The aromatic and aliphatic esters are both competent electrophiles and thus broaden the substrate scope of esters in coupling reactions, because the electrophiles in previously reported work were strictly limited to aromatic ones.

Efficacy and safety of the combination of anlotinib and envafolimab in the treatment of unresectable or metastatic liposarcoma: findings from a single-center retrospective study.

Objective: To evaluate the efficacy and safety of anlotinib combined with envafolimab in the treatment of unresectable or metastatic liposarcoma.

Methods: This single-center, retrospective study enrolled 15 patients with unresectable or metastatic liposarcoma, who were treated at the Retroperitoneal Tumor Surgery Research Center of Qingdao University Affiliated Hospital between April 2022 and November 2023. The treatment regimen consisted of anlotinib combined with envafolimab.