Extended time-of-flight measurements down to 100 keV at the AMANDE facility with a stilbene scintillator.

The time-of-flight (ToF) method with scintillators is routinely used for determining neutron energy. However, a technical difficulty related to the loss of scintillator efficiency below 1 MeV makes this technique difficult to implement for the energy decade [100 keV-1 MeV]. New crystal production techniques provide stilbene scintillators efficient in this low neutron energy region, making it possible to extend the ToF technique below 1 MeV.

Characterization of CRISPR/Cas9-edited human placental allogenic stromal cells with low tissue factor expression and reduced thrombotic effects.

The tissue factor (TF/CD142) expressed by mesenchymal stromal cells (MSCs) has been regarded as a safety concern in clinical applications as it may trigger thrombosis when MSCs administered intravenously. Human placental allogenic stromal cells (ASCs) are culture-expanded, undifferentiated MSC-like cells derived from full-term postpartum placenta and possess immunomodulatory and pro-angiogenic activities, however, express TF. Here we performed CRISPR/Cas9-mediated TF gene knock out (TFKO) in ASCs, leading to significantly lower TF expression, activity and thrombotic effects.

Tramadol for the Management of Opioid Withdrawal: A Systematic Review of Randomized Clinical Trials.

The increase in the prescription of opioid medications has resulted in a wildfire of misuse of opioids, both for medical and non-medical reasons, with over 1.7 million people in the United States (US) suffering from distinct disorders owing to opioid use. While various medications, such as methadone, buprenorphine, and naloxone, among others, have been used in treating opioid withdrawal symptoms, concerns of the potential abuse of these drugs, the cost of procurement, legislations, and prescription policies have risen.

Clarifying the role of belief-motive explanations in multi-stakeholder realist evaluation.

In realist evaluation, where researchers aim to make program theories explicit, they can encounter competing explanations as to how programs work. Managing explanatory tensions from different sources of evidence in multi-stakeholder projects can challenge external evaluators, especially when access to pertinent data, like client records, is mediated by program stakeholders. In this article, we consider two central questions: how can program stakeholder motives shape a realist evaluation project; and how might realist evaluators respond to stakeholders' belief-motive explanations, including those about program effectiveness, based on factors such as supererogatory commitment or trying together in good faith? Drawing on our realist evaluation of a service reform initiative involving multiple agencies, we describe stakeholder motives at key phases, highlighting a need for tactics and skills that help to manage explanatory tensions.

Scattering matrix of arbitrarily shaped objects: combining finite elements and vector partial waves.

We demonstrate the interest of combining finite element calculations with the vector partial wave formulation (used in T-matrix and Mie theory) in order to characterize the electromagnetic scattering properties of isolated individual scatterers. This method consists of individually feeding the finite element problem with incident vector partial waves in order to numerically determine the T-matrix elements of the scatterer. For a sphere and a spheroid, we demonstrate that this method determines the scattering matrix to high accuracy.