[Antihomotoxic drug therapy of endothelial function disorder in patients with hypertension].

A multimodality therapy of patients with hypertensive disease involving the institution of basic conventional therapy and antihomotoxic preparations Hepar compositum and Ubichinon composition (Heel, Germany) has been shown to promote restoration of the degree of initial postischemic constriction but without normalization of responsiveness of vessels to the ischemic factor and nitroglycerin. Administration of antihomotoxic drugs exerted apparent optimizing effect on the state of the endothelial function that was manifested by returning parameters characterizing initial postischemic vasoconstriction and maximum postischemic vasodilatation to normal with high responsiveness to the endothelium-independent vasodilator nitroglycerin being maintained.