First report on QSAR modelling for chemical penetration enhancement ratio (ER) of different FDA-approved drugs in Poloxamer 407: A next step towards better skin permeability of drugs.

Poloxamer 407 is a versatile excipient that enhances drug solubilization and prolongs drug release. Poloxamers are non-ionic tri-block copolymers composed of a central hydrophobic chain of polyoxypropylene flanked by two hydrophilic chains of polyoxyethylene. Various researchers have utilized Poloxamer 407 in topical and transdermal drug delivery systems, and it has also been reported to enhance skin permeability.

Leveraging machine learning to predict drug permeation: impact of menthol and limonene as enhancers.

The present study aimed to develop robust machine learning (ML) models to predict the skin permeability of poorly water-soluble drugs in the presence of menthol and limonene as penetration enhancers (PEs). The ML models were also applied in virtual screening (VS) to identify hydrophobic drugs that exhibited better skin permeability in the presence of permeation enhancers i.e.

Features, reasons, and significance of radon and thoron attributable radiological dose in the indoor environment.

Humans receive around 50% of natural radiation dose due to Rn (radon), Rn (thoron) and their decay products. Several field campaigns measuring these gases and the decay products in different regions of India have been conducted in the recent past. Some of these studies measured indoor activity concentration and/or dose due to these gases and the associated decay products.

Assessment of local diagnostic reference levels (LDRLS) for full-field digital mammography (FFDM) and digital breast tomosynthesis (DBT) mammography in Tamil Nadu, India.

The purpose of this study was to assess local diagnostic reference levels (LDRLs) for full-field digital mammography (FFDM) and digital breast tomosynthesis (DBT) mammography in India. Data from 1500 women were collected from five different mammography facilities in major cities in Tamil Nadu, India. The mean of mean glandular dose were used to arrive at an LDRL.

Thoron exposure in the radon-thoron prone area of the Adamawa Region, Cameroon.

The radon-prone area of the Adamawa region is characterized by high radon concentrations, where no low-risk area was observed. This study aims to investigate about indoor thoron concentration in this area, using RADUET detectors, thoron progeny monitors and DTPS/DRPS. The indoor thoron concentration ranged between 17 and 1000 Bq m, with an average of 131 Bq m.