Thermocontrolled Radical Nucleophilicity vs Radicophilicity in Regiodivergent C-H Functionalization.

The temperature-dependent switching behavior of the saccharin radical is demonstrated, enabling the regiodivergent C-H and C-H functionalization of quinoxalin-2(1)-ones. The saccharin radical was generated through N-Br bond cleavage in -bromosaccharin (NBSA) and was observed to transition between radical and radicophile roles. At -10 °C, it was utilized as a radicophile, resulting in 100% C-amination, while at +35 °C, it acted as a radical, leading to exclusive C-bromination.

Serum Levels of Heavy Metals in Patients with Prostate Cancer: A Systematic Review and Meta-analysis.

Prostate cancer (PC) is a common malignancy among men globally. Although genetic, hormonal, and environmental factors contribute to its development, the role of heavy metals remains unclear. This study evaluated serum levels of arsenic, cadmium, lead, mercury, and nickel in PC patients compared to healthy controls.

Outcomes of Standard-Risk Multiple Myeloma Patients Who Undergo Upfront Autologous Hematopoietic Stem Cell Transplantation.

Patients with multiple myeloma (MM) without high-risk cytogenetic abnormalities are classified as having standard-risk MM (SRMM), and data focusing on their outcomes after autologous hematopoietic stem cell transplantation (autoHCT) are limited. To evaluate survival outcomes for patients with SRMM receiving autoHCT, and to elucidate factors that impact these outcomes. Single-center retrospective analysis that included consecutive MM patients who received upfront autoHCT between 2013 and 2021, had available cytogenetic information and had no high-risk chromosomal abnormalities on fluorescence in situ hybridization, defined as t(4;14), t(14;16), del(17p) or 1q21 gain or amplification.

Prevalence of antihypertensive medication adherence and associated factors in India: A systematic review and meta-analysis.

Background: Non-adherence to antihypertensive medication is a key factor contributing to uncontrolled blood pressure and the subsequent complications of hypertension. Despite its importance, there is a lack of data regarding the prevalence of and factors associated with non-adherence to medication among individuals with hypertension in India. This review aimed to assess medication adherence rates among hypertensive patients in India and identify the factors influencing non-adherence.

Open laminectomy plus posterolateral fusion versus open laminectomy plus transforaminal lumbar interbody fusion surgical approaches for fusing degenerated L4-L5 segment: A comparative finite element study.

Various finite element (FE) studies reported the biomechanical effects of fusion surgeries in the lumbar spine. However, a comparative study on Open laminectomy plus Posterolateral Fusion (OL-PLF) and Open Laminectomy plus Transforaminal Lumbar Interbody Fusion (OL-TLIF) for fusing an L4-L5 segment has not been reported in the literature. The present comparative FE study evaluates the biomechanical variations in an L4-L5 segment fused using OL-PLF and OL-TLIF surgical approaches.