Publications by authors named "B K McElwain"
Article Synopsis
- Scientists found it tough to study how proteins work during different parts of the cell cycle because of treatment methods that change how cells grow.
- They created a new system called ROLECCS that lets them control protein breakdown in specific cell cycle phases without interfering with the cells too much.
- Using this new system, they learned that a protein called TP53, which helps stop cancer, behaves differently when taken away during certain phases of the cell cycle.
MicroRNA-21 (miR-21) inhibits IL-12 expression and impairs the Th1 response necessary for control of infection. Recent studies have shown that infection induces miR-21 expression in dendritic cells and macrophages, and inhibition of miR-21 restores IL-12 expression. Because miR-21 is known to be expressed due to inflammatory stimuli in a wide range of hematopoietic cells, we investigated the role of miR-21 in regulating immune responses during visceral leishmaniasis (VL) caused by infection.
View Article and Find Full Text PDFHuman leukocyte antigen (HLA) Class II antigens are variably expressed on acute myeloid leukemia (AML) blasts. The biological and clinical significance of HLA Class II antigen expression by AML cells is not known. Therefore, we sought to characterize cases of AML without detectable HLA-DR expression.
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