Publications by authors named "B K McConnell"
Aims: Sex and gender may influence penicillin allergy label (PAL) prevalence and outcomes. This review evaluates the effectiveness and safety of direct delabelling (DD) and oral challenge (OC) for low-risk patients and examines sex and gender differences in reporting and outcomes.
Methods: We searched PubMed, Database of Abstracts of Reviews and Effects, ClinicalTrials.
This review outlines some of the many approaches taken over a decade or more to repair damaged hearts. We showcase the recent breakthroughs in organ regeneration elicited by reprogramming factors OCT3/4, SOX2, KLF4, and C-MYC (OKSM). Transient OKSM transgene expression rejuvenated senescent organs in mice.
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- Around 10% of people claim to have a penicillin allergy, but over 90% can be cleared of this designation through thorough assessments, with oral challenges being an acceptable method for low-risk cases.
- The systematic review will analyze the effectiveness and safety of interventions aimed at removing penicillin allergies while also examining the impact of sex and gender on allergy reporting and patient outcomes.
- The review will follow established guidelines for systematic research, excluding studies that require preliminary penicillin skin testing, and will involve detailed data extraction across multiple levels to ensure comprehensive analysis.
Mammalian cell culture processes are widely utilized for biotherapeutics production, disease diagnostics, and biosensors, and hence, should be optimized to support robust cell growth and viability. However, toxic by-products accumulate in cultures due to inefficiencies in metabolic activities and nutrient utilization. In this study, we applied comprehensive C stable-isotope tracing of amino acids and glucose to two Immunoglobulin G (IgG) producing Chinese Hamster Ovary (CHO) cell lines to identify secreted by-products and trace their origins.
View Article and Find Full Text PDFLysophosphatidic Acid Signaling in the Gastrointestinal System.
Cell Mol Gastroenterol Hepatol
November 2024
The intestinal epithelium undergoes continuous homeostatic renewal to conduct the digestion and absorption of nutrients. At the same time, the intestinal epithelial barrier separates the host from the intestinal lumen, preventing systemic infection from enteric pathogens. To maintain homeostasis and epithelial functionality, stem cells, which reside in the base of intestinal crypts, generate progenitor cells that ultimately differentiate to produce an array of secretory and absorptive cells.
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