SGLT2-Inhibition in Patients With Alport Syndrome.

Introduction: Large-scale trials showed positive outcomes of sodium-glucose cotransporter-2 inhibitors (SGLT2i) in adults with chronic kidney disease (CKD). Whether the use of SGLT2i is safe and effective in patients with the common hereditary CKD Alport syndrome (AS) has not yet been investigated specifically in larger cohorts.

Methods: This observational, multicenter, international study (NCT02378805) assessed 112 patients with AS after start of SGLT2i.

The Effect of Motivational Interviewing on Caregiver Facilitation of Home Practice.

The purpose of the investigation was to determine the feasibility of motivational interviewing (MI) to increase caregiver facilitation of articulation home practice. The number of completed caregiver-facilitated practice sessions was collected daily throughout the investigation. MI was introduced to three caregivers who all identified feelings of ambivalence surrounding home practice.

Relevance of high glycaemic index breakfast for heart rate variability among collegiate students with early and late chronotypes.

Plasma glucose spikes affect cardiac autonomic modulation resulting in a decrease of heart rate variability (HRV). We hypothesize that a later chronotype or a higher morning plasma melatonin level is associated with larger decreases of HRV following an early high glycaemic index (GI) breakfast. In persons with an early ( = 21) or a late ( = 15) chronotype who consumed a high GI breakfast at 7 a.