Publications by authors named "B K Khajanchi"
The global incidence of serovar Schwarzengrund has risen in recent years. This serotype has been isolated from poultry, retail meat, and other food products, leading to multiple outbreaks. Alongside the increase in infections, there are growing concerns about the increasing levels of antimicrobial resistance (AMR) among Schwarzengrund strains.
View Article and Find Full Text PDFA total of 55 food and clinical . Schwarzengrund isolates were assayed for plasmid content, among which an IncFIB-IncFIC(FII) fusion plasmid, conferring streptomycin resistance, was detected in 17 isolates. Among the 17 isolates, 9 were food isolates primarily collected from poultry meat, and 8 clinical isolates collected from stool, urine, and gallbladder.
View Article and Find Full Text PDFSeventeen serovar Schwarzengrund isolates from chicken ( = 9) and clinical samples including stool ( = 6), urine ( = 1), and gallbladder ( = 1) were sequenced and found to carry an IncFIB-IncFIC (FII) fusion plasmid of approximately 145 Kb. This information provides reference genomic data for comparative studies of . Schwarzengrund pathogenicity and plasmid genetics.
View Article and Find Full Text PDFArticle Synopsis
- Type IV secretion systems (T4SSs) in enteric bacteria are crucial for the process of conjugation, enabling the transfer of antimicrobial resistance (AMR) genes found on plasmids.
- A database was created from key conjugation genes associated with AMR plasmids, sourced from GenBank, to aid in the analysis and comparison of these genes and their sequences across different plasmid types.
- Two analysis tools were developed to evaluate and compare plasmid transfer genes, significantly enhancing our understanding of how conjugative plasmids contribute to the spread of AMR genes.
Article Synopsis
- The antimicrobial resistance (AMR) mobilome is crucial in spreading resistance genes through mobile genetic elements like plasmids and transposons, significantly contributing to multidrug resistance in bacteria and posing a global health risk.
- Multiple sequence-based computational techniques were employed to analyze 1,309 complete plasmid sequences from various bacterial species, enabling the detection of AMR genes and insertion sequences, utilizing databases and web tools for analysis.
- The findings revealed a diverse distribution of resistance genes across plasmids, indicating that mobile genetic elements facilitate the transmission of these genes, suggesting a complex interplay between various plasmid types and their associated resistance mechanisms.