Publications by authors named "B K England"
Background: Idiopathic interstitial pneumonias (IIPs), such as idiopathic pulmonary fibrosis and interstitial pneumonia with autoimmune features, present diagnostic and therapeutic challenges due to their heterogeneous nature. This study aimed to identify intrinsic molecular signatures within the lung microenvironment of these IIPs through proteomic analysis of bronchoalveolar lavage fluid (BALF).
Methods: Patients with IIP (n=23) underwent comprehensive clinical evaluation including pre-treatment bronchoscopy and were compared with controls without lung disease (n=5).
Objectives: To evaluate patient preferences for decision-making role in the management of intraductal papillary mucinous neoplasms (IPMNs) of the pancreas and to identify individual characteristics associated with those preferences.
Background: Management of IPMNs is rooted in uncertainty with current guidelines failing to incorporate patients' preferences and values.
Methods: A representative sample of participants aged 40-70 were recruited to evaluate a clinical vignette where they were given the option to undergo surveillance or surgical resection of their IPMN.
Article Synopsis
- - The Veterans Affairs (VA) system plays a key role in researching rheumatoid arthritis (RA) due to its extensive resources and reach within the U.S. healthcare system.
- - The VA Rheumatoid Arthritis Registry (VARA) features over 3,600 participants from 19 medical centers, providing rich longitudinal clinical data and biological samples, enhancing research capabilities.
- - With strong connections to various internal and external databases, VARA is well-positioned to tackle significant RA-related research questions in the future.
The objective of this study was to assess fibrinogen (FIB) co-modified with citrulline (CIT) and/or malondialdehyde-acetaldehyde (MAA) initiates macrophage-fibroblast interactions leading to extracellular matrix (ECM) deposition that characterizes rheumatoid arthritis-associated interstitial lung disease (RA-ILD). Macrophages (Mϕ) were stimulated with native-FIB, FIB-CIT, FIB-MAA or FIB-MAA-CIT. Supernatants (SN) (Mϕ-SN [U-937-derived] or MϕP-SN [PBMC-derived]) or direct antigens were co-incubated with human lung fibroblasts (HLFs).
View Article and Find Full Text PDFRheumatoid arthritis-associated interstitial lung disease: Advancing the identification and management.
Semin Arthritis Rheum
November 2024
Article Synopsis
- - Interstitial lung disease (ILD) is a serious complication of rheumatoid arthritis (RA) that significantly impacts patient health, but effective screening and management strategies are still lacking.
- - Recent research underscores the need for improved identification of RA-ILD through accurate risk stratification and the exploration of peripheral biomarkers to support personalized medicine approaches.
- - There is a critical need for randomized trials to evaluate treatments for RA-ILD, especially immunomodulatory therapies, to develop evidence-based management strategies.