Publications by authors named "B K Coombes"
Objective: Epidemiological studies suggest that patients with attention-deficit/hyperactivity disorder (ADHD) treated with amphetamines have an increased risk of newly diagnosed psychosis. This risk in youth is poorly understood. This investigation studied the potential risk of newly diagnosed psychotic symptoms associated with exposure to 4 classes of ADHD medications.
View Article and Find Full Text PDFLasso peptides, biologically active molecules with a distinct structurally constrained knotted fold, are natural products belonging to the class of ribosomally-synthesized and posttranslationally modified peptides (RiPPs). Lasso peptides act upon several bacterial targets, but none have been reported to inhibit the ribosome, one of the main antibiotic targets in the bacterial cell. Here, we report the identification and characterization of the lasso peptide antibiotic, lariocidin (LAR), and its internally cyclized derivative, lariocidin B (LAR-B), produced by .
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- Treatment resistance in major depressive disorder (MDD) is common, but its clinical risk factors are not well understood, prompting this study using data from electronic health records.
- The researchers conducted phenome-wide association studies (PheWAS) to identify factors linked to treatment resistance, revealing 180 significant phecodes in a large sample, with 71 replicated in a second group.
- They found that the number of unique antidepressants prescribed correlates with various clinical conditions, suggesting both clinical and genetic factors affect treatment resistance, which could enhance future research and clinical practices.
Due to its dynamic nature, lower limb injuries are common in badminton. Overuse injuries of the knee, including tendon related conditions, are the most common. During jumping and landing, force transference and dissipation through the trunk is required, with the trunk muscles playing a vital role.
View Article and Find Full Text PDFBackground: Many patients with bipolar disorder (BD) do not respond to or have difficulties tolerating lithium and/or other mood stabilizing agents. There is a need for personalized treatments based on biomarkers in guiding treatment options. The calcium voltage-gated channel CACNA1C is a promising candidate for developing personalized treatments.
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