Publications by authors named "B K Binukumar"

Article Synopsis
  • The study investigates the role of a master regulator gene in the development of excitatory neurons, specifically focusing on its function in cerebellar granule neuron progenitors (GNPs).
  • Researchers found that dysfunction of this gene in GNPs reduced their proliferation and led to various cerebellar abnormalities, including hypoplasia and imbalances in neuron ratios.
  • The findings suggest that deletion of this gene during early development can cause autism-like behaviors in mice and highlight uncharacterized gene variants associated with autism spectrum disorder in humans.
View Article and Find Full Text PDF

Oligodendrocytes, crucial myelinating glia in the central nervous system, play a vital role in maintaining axonal integrity and facilitating efficient nerve impulse conduction. The degradation of myelin in oligodendrocytes has been implicated in Alzheimer's disease (AD) and cognitive dysfunction. Interestingly, individuals with Type 2 Diabetes (T2D) have a significantly higher likelihood of developing cognitive impairment, possibly due to insulin resistance and glucose toxicity within the central nervous system (CNS).

View Article and Find Full Text PDF

Aim: Gestational diabetes mellitus (GDM) might predispose the mothers to depression. Studies have reported the role of biomarkers either in GDM or depression, but very few have examined them in GDM with depression. The present study profiled the circulating levels of brain-derived neurotrophic factor (BDNF), Beta Endorphin (BE) and nesfatin-1 in women with GDM (with and without depression).

View Article and Find Full Text PDF

Outcomes of pallidal stimulation in dystonia have been infrequently reported prospectively. We report the six-month outcomes of bilateral GPi DBS in an Asian Indian patient with early-onset generalized dystonia associated with a novel heterozygous variant in the gene.

View Article and Find Full Text PDF

Background: Coronary heart disease, a leading cause of death globally, is amenable to lifestyle interventions. The family environment can affect the ability or willingness of individuals to make lifestyle changes. We aimed to investigate the efficacy of a targeted family-based intervention for reduction of total cardiovascular risk in individuals with a family history of premature coronary heart disease.

View Article and Find Full Text PDF