Analysis of Femoral Flexion Angle Distribution and Range of Motion in Total Knee Arthroplasty.

Background: Optimal coronal and rotational alignment in total knee arthroplasty is essential for satisfactory outcomes. There has been limited focus on sagittal alignment in assessing outcomes. This study investigated the impact of femoral implant flexion (FF) angle on knee kinematics and postoperative outcomes.

Hydroxylation of dihydromyricetin via Beauveria bassiana fermentation enhances its efficacy in improving insulin signaling: Insights into inflammation, oxidative stress, and endoplasmic reticulum stress.

Chronic metabolic diseases, particularly insulin resistance (IR) and diabetes, pose significant global health challenges. This study introduces a novel hydroxylated dihydromyricetin (DHM) derivative, 8-hydroxy-DHM (H-DHM), produced via microbial fermentation using Beauveria bassiana. Notably, hydroxylation significantly enhances the efficacy of DHM in glucose consumption, glycogen synthesis, and glucose transport, while inhibiting gluconeogenesis in an IR-HepG2 cell model.

Parity and breastfeeding are contributing factors for geographical differences in breast cancer risk.

Purpose: Urbanization has emerged as one of the main determinants of the rising breast cancer incidence in Asia, but understanding the link is hindered by the lack of population-based prospective cohorts, especially in low- and middle-income countries. Given that mammographic density (MD) is one of the strongest breast cancer risk factors and that it is associated with known lifestyle and reproductive factors, we explored using MD to delineate factors associated with differences in breast cancer risk between women living in urban and rural areas.

Methods: Using data from a cross-sectional study of 9,417 women living in urban or rural areas recruited through hospital- or community-based opportunistic mammography screening programs, we conducted regression and mediation analyses to identify factors contributing to the differences in MD between urban and rural populations across Asian ethnic subgroups.

Unraveling Online Mental Health Through the Lens of Early Maladaptive Schemas: AI-Enabled Content Analysis of Online Mental Health Communities.

Background: Early maladaptive schemas (EMSs) are pervasive, self-defeating patterns of thoughts and emotions underlying most mental health problems and are central in schema therapy. However, the characteristics of EMSs vary across demographics, and despite the growing use of online mental health communities (OMHCs), how EMSs manifest in these online support-seeking environments remains unclear. Understanding these characteristics could inform the design of more effective interventions powered by artificial intelligence to address online support seekers' unique therapeutic needs.

Integrating Metal-Organic Framework Hybrid into Nucleic Acid-Based Hydrogel for Highly Selective Recognition and Sensitive Detection of Sarafloxacin.

Metal-organic framework-based hybrids (MOFzyme) have promising applications in colorimetric aptasensors due to their highly efficient and stable catalytic activity. However, their efficient application in biosensors remains a challenging issue due to the limited reaction site and amorphous structure. Herein, we encapsulated catalase inside MOF cavities to prepare an MOFzyme with many functional groups on its surface, and the functional groups were utilized for the subsequent integration of MOFzyme into the hyaluronic acid-DNA hydrogel.