Differences in immunoreactivity of estrogen receptor (ER) in tamoxifen-sensitive and -resistant breast carcinomas: preclinical and first clinical investigations.

Inherited or acquired tamoxifen resistance is a major constraint in the endocrinological treatment of breast carcinomas. We developed an enzyme-immunoassay that discriminates between tamoxifen-sensitive and -resistant tumors. The procedure was established and standardized using two xenografted breast carcinomas--3366 (highly sensitive to tamoxifen) and 3366/TAM (acquired tamoxifen resistance).

[Course of listeriosis infection in pregnancy after early therapy].

Due to unspecific symptoms, listeriosis during pregnancy is often not diagnosed until the late stages of the disease. After materno-foetal infection, the usual fate of the unborn child is premature delivery. We present a case, where foetal infection was prevented by early antibiotic treatment.