The effects of early short-term insulin treatment vs. glimepiride on beta cell function in newly diagnosed type 2 diabetes with HbA1c above 9.

Background: Type 2 diabetes mellitus (T2D) is a complex metabolic impairment. Beta cell (BC) failure is the most challenging among its pathogenetic mechanisms. Recognizing reversible contributors to BC failure could guide individualized approach to early T2D treatment.

The translationally controlled tumor protein TCTP is involved in cell cycle progression and heat stress response in the bloodstream form of .

The translationally controlled tumor protein TCTP, is a universally conserved protein that seems to be of essential function in all systems tested so far. TCTP is involved in a multitude of cellular functions including cell cycle control, cell division, apoptosis and many more. The mechanism of how TCTP is involved in most of these functions remains elusive.

Distinct 3' UTRs regulate the life-cycle-specific expression of two paralogs in .

The translationally controlled tumor protein (TCTP; also known as TPT1 in mammals) is highly conserved and ubiquitously expressed in eukaryotes. It is involved in growth and development, cell cycle progression, protection against cellular stresses and apoptosis, indicating the multifunctional role of the protein. Here, for the first time, we characterize the expression and function of TCTP in the human and animal pathogen, We identified two paralogs ( and ) that are differentially expressed in the life cycle of the parasite.

Obesity and metabolic syndrome during the menopause transition in Serbian women.

Background: Abdominal obesity and metabolic syndrome are known to increase in prevalence from premenopause to postmenopause. Both are well recognized predictors of cardiovascular disease and diabetes in women. Aims The primary objective of this study was to assess the presence of obesity and metabolic syndrome during the menopause transition in Serbian women who attended health-care centers.

[Review of the extratransference intervention practice in the psychoanalytic psychotherapy].

The transference analysis takes the central position of the work in psychoanalytic psychotherapy. The work in extratransference sphere and experience in practical work with extratransference interventions are not often reported in expert literature. Extratransference sphere includes less transferring relation to the psychotherapist, transference on the other objects, or may refer to the external reality rather than the psychic reality or fantasy.