Immunogenic dying cells elicit potent anti-tumor T cell immunity against lung metastasis and tumorigenesis.

Purpose: Immune checkpoint blockades (ICBs) are promising, however they do not fit all types of tumor, such as those lack of tumor antigens. Induction of potent anti-tumor T cell immunity is critical for cancer therapy. In this study, we investigated the efficacy of immunotherapy via the immunogenic cell death (ICD) dying tumor cells in mouse models of lung metastasis and tumorigenesis.

Inorganic substrates in frozen solutions: Transformation mechanisms and interactions with organic compounds - A review.

In cold environments, such as polar regions and high latitudes, the freezing of aqueous solutions plays a crucial role in releasing and transforming nutrients, organic compounds, and trace gases. Freezing processes typically affect biogeochemical cycles and environmental processes by reducing the rate of chemical reactions. However, substantial studies have found that some chemical reactions may accelerate unexpectedly under freezing conditions.

Antihypertensive Deprescribing and Functional Status in VA Long-Term Care Residents With and Without Dementia.

Background: Deprescribing antihypertensives is of growing interest in geriatric medicine, yet the impact on functional status is unknown. We emulated a target trial of deprescribing antihypertensive medications compared with continued use on functional status measured by activities of daily living (ADL) in a long-term care population.

Methods: We included 12,238 Veteran Affairs long-term care residents age 65+ who had a stay ≥ 12 weeks between 2006 and 2019.

YOLO-OD: Obstacle Detection for Visually Impaired Navigation Assistance.

Visually impaired individuals frequently encounter difficulties in detecting and avoiding obstacles in the wild. To address this issue, we propose an obstacle detection method for visual navigation assistance, named YOLO-OD. To improve the ability to detect and differentiate between different sized obstacles in outdoor environments, we introduce the Feature Weighting Block (FWB), which improves feature importance discrimination.

Effects of Hygrothermal Condition on Water Diffusion and Flexural Properties of Carbon-Glass Hybrid Fiber-Reinforced Epoxy Polymer Winding Pipes.

Carbon-glass hybrid fiber-reinforced epoxy polymer (C-GFRP) winding pipes integrated with the advantages of light weight, high strength, corrosion resistance, and cost-effectiveness offer immense potential to mitigate corrosion issues in oil, gas, and water transportation pipelines. In this study, C-GFRP winding pipes underwent accelerated aging tests through immersion in distilled water at temperatures of 25 °C, 40 °C, and 60 °C for 146 days. Water absorption tests were conducted to investigate the water absorption behavior of only CFRP- or GFRP-side absorbed water.