Publications by authors named "B Jasperse"
Background: Multiple sclerosis (MS) is characterized by extensive tissue damage leading to a range of complex symptoms, including physical disability and cognitive dysfunction. Recent work has indicated the clinical relevance of bioactive lipid mediators (LMs), which are known to orchestrate inflammation and its resolution and are deregulated in MS. However, it is unknown whether LM profiles relate to white matter (WM) damage.
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- - This study aimed to evaluate how reliable automatic lesion segmentation tools are when used on MRI scans of people with multiple sclerosis (pwMS) across different scanners, focusing on their repeatability and accuracy compared to manual segmentation methods.
- - Researchers scanned 30 pwMS using three different MRI machines (two 3.0 T and one 1.5 T) and employed various segmentation techniques, including both automated tools and manual methods, to measure their effectiveness.
- - Results showed that optimizing the segmentation settings for each specific scanner significantly improved accuracy (measured by the Dice similarity coefficient) for one of the software tools (LST) compared to using default settings or a combined approach.
Background: Digital monitoring of people with multiple sclerosis (PwMS) using smartphone-based monitoring tools is a promising method to assess disease activity and progression.
Objective: To study cross-sectional and longitudinal associations between active and passive digital monitoring parameters and MRI volume measures in PwMS.
Methods: In this prospective study, 92 PwMS were included.
Spinal cord MRI plays an important role in the diagnosis and prognosis of multiple sclerosis (MS) and related disorders. The ANATOMICAL, pathologic, imaging and prognostic consideriations for the spinal cord for MS and the most important other demyelinating disorders, neuromyelitis optica spectrum disorder and myelin oligodendrocyte glycoprotein-associated disease, are reviewed. Finally, differential diagnostic considerations of spinal cord MRI in MS and related disorders are discussed.
View Article and Find Full Text PDFBackground: The long-term effect of high efficacy disease modifying therapy (DMT) on neurodegeneration in people with multiple sclerosis (pwMS) is largely unknown. The aim of this study was to evaluate the long-term effect of natalizumab (NTZ) or fingolimod (FTY) therapy on the evolution of brain atrophy compared to moderate efficacy DMT in a real-world clinical setting.
Methods: A total of 438 pwMS with 2,439 MRI exams during treatment were analyzed: 252 pwMS treated with moderate efficacy DMT, 130 with NTZ and 56 with FTY.