Publications by authors named "B Jason West"
Cetylpyridinium chloride (CPC) is a quaternary ammonium antimicrobial used in numerous personal care products, human food, cosmetic products, and cleaning solutions. Yet, there is minimal published data on CPC effects on eukaryotes, immune signaling, and human health. Previously, it was shown that low-micromolar CPC inhibits rat mast cell function by inhibiting antigen (Ag)-stimulated Ca mobilization, microtubule polymerization, and degranulation.
View Article and Find Full Text PDFTranscriptomics as a predictor of biopharmaceutically favourable glycan profiles.
Front Cell Dev Biol
December 2024
Article Synopsis
- Glycosylation significantly influences the pharmacological properties of biologics, leading to variability in their glycan structures and posing challenges for consistent therapeutic development.
- The study uses omics technologies, specifically RNA-sequencing, to predict optimal cell lines for producing specific glycosylation profiles in monoclonal antibodies (mAbs), identifying Alg5 and UDP-Gal transporter levels as key predictive markers.
- While transcriptomic data is useful in forecasting glycosylation trends, it fails to capture important factors like enzyme localization and cellular dynamics that are crucial for the actual outcomes of glycosylation.
Background: Glioblastoma (GBM) has a median survival of <2 years. Pexidartinib (PLX3397) is a small-molecule inhibitor of CSF1R, KIT, and oncogenic FTL3, which are implicated in GBM treatment resistance. Results from glioma models indicate that combining radiation therapy (RT) and pexidartinib reduces radiation resistance.
View Article and Find Full Text PDFBackground And Aims: An exploratory focus group study was conducted to better understand the needs of patients living with generalized myasthenia gravis (gMG).
Methods: US-based adults with gMG and caregivers of patients with gMG participated in a Patient Engagement Research Council between August 2022 and January 2023. The study consisted of a 15-min prework survey, followed by virtual focus groups facilitated using a semi-structured interview guide.