Publications by authors named "B Jabri"
Article Synopsis
- Bloodstream infections need quick bacterial identification for effective treatment, with traditional methods being slow.
- The study compared direct identification using MALDI-TOF MS with the post-culture method, finding that while direct identification had a lower success rate (64.8%), it provided results in under an hour.
- Despite its limitations, the direct method could significantly enhance diagnosis speed, making it a potentially valuable tool in conjunction with established methods.
Article Synopsis
- - The study focuses on improving the analysis of high-content images from multiplexed microscopy to better understand cells within their native tissue, highlighting the need for stronger computational tools to interpret these complex images.
- - The authors introduce a new method called pseudo-spectral angle mapping (pSAM), which effectively classifies each pixel in high-plex images, enabling better identification of different cell types.
- - Results demonstrate that pSAM successfully classifies diverse cell types in datasets from colon and kidney biopsies, proving its effectiveness as a versatile tool for analyzing high-plex immunofluorescence data.
Unlabelled: Understanding the initiation of T-helper (Th)-2 immunity is crucial for addressing allergic diseases that have been linked to the commensal microbiota. However, Th2 responses are notably absent from known host-microbiota intestinal immune circuits. Notably, the commensal protist induces a transient innate ILC2 circuit rather than a chronic Th2 circuit.
View Article and Find Full Text PDFNatural killer (NK) cells traffic through the blood and mount cytolytic and interferon-γ (IFNγ)-focused responses to intracellular pathogens and tumors. Type 1 innate lymphoid cells (ILC1s) also produce type 1 cytokines but reside in tissues and are not cytotoxic. Whether these differences reflect discrete lineages or distinct states of a common cell type is not understood.
View Article and Find Full Text PDFCeliac disease (CeD) is a gluten-induced enteropathy that develops in genetically susceptible individuals upon consumption of cereal gluten proteins. It is a unique and complex immune disorder to study as the driving antigen is known and the tissue targeted by the immune reaction can be interrogated. This review integrates findings gained from genetic, biochemical, and immunologic studies, which together have revealed mechanisms of gluten peptide modification and HLA binding, thereby enabling a maladapted anti-gluten immune response.
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