Publications by authors named "B J Wilkins"
Background: The Fontan operation is the current standard of care for single-ventricle congenital heart disease. Almost all patients with Fontan operation develop liver fibrosis at a young age, known as Fontan-associated liver disease (FALD). The pathogenesis and mechanisms underlying FALD remain little understood, and there are no effective therapies.
View Article and Find Full Text PDFSex differences in the maximal metabolic steady state of fitness-matched women and men.
J Appl Physiol (1985)
February 2025
We tested the hypothesis that power at maximal metabolic steady state is similar between fitness-matched men and women. Eighteen participants (9 men and 9 women) performed a cycling graded exercise test for maximal oxygen consumption (V̇o). Men and women were matched for V̇o normalized to fat-free mass (FFM), which was 50.
View Article and Find Full Text PDFUnlabelled: Parents often point to bedtime as a source of frustration, yet early bedtimes and sufficient sleep are important for children's development, learning, and behavior.
Objectives: This pilot study aimed to assess the feasibility and preliminary effectiveness of a yoga-based bedtime routine in a sample of parent-child dyads from a rural community.
Methods: Using a waitlist control study design, children aged 2-5 years and their parent were randomized to either intervention (yoga) or control (bedtime story) groups.
Article Synopsis
- Adenovirus has been linked to acute liver failure (ALF), prompting a study on the prevalence of various viruses in children who underwent liver transplants due to liver diseases.
- The study analyzed 33 liver samples, finding HHV-6 in the majority of cases, while adenovirus was only detected in one ALF case, suggesting it may not significantly contribute to liver failure.
- The findings highlight HHV-6 as the most common virus in liver transplant cases, providing foundational data for understanding viral links to ALF.
Article Synopsis
- - Cholangiopathies are complex disorders with limited understanding and no effective treatments, prompting a study on the extrahepatic biliary tree (EHBD) in Mdr2 mice, a cholestatic mouse model, across different ages (2 to 40 weeks).
- - The study assessed the effects of N-acetyl-L-Cysteine (NAC), an antioxidant and glutathione precursor, on EHBD injury both ex vivo (using bile duct samples) and in vivo (through oral administration for three weeks).
- - Results showed that NAC treatment improved bile duct morphology and reduced liver fibrosis along with lower liver enzyme levels, suggesting a shift in cellular state from apoptosis to proliferation, indicating NAC's potential as a therapeutic