Publications by authors named "B J Trock"
Background: The transcription factor Signal Transducer and Activator of Transcription 3 (STAT3) plays a role in carcinogenesis and is involved in processes, such as proliferation, differentiation, drug resistance and immunosuppression. STAT3 can be activated by phosphorylation of tyrosine at position 705 (pSTAT3) or serine at 727 (pSTAT3). High expression levels of pSTAT3 are implicated in advanced stages of prostate cancer (PCa) and are known to interact with the androgen receptor signaling pathway.
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- The study examines whether diet quality and inflammatory potential affect the risk of prostate cancer grade reclassification in men under active surveillance, revealing that diet's influence remains uncertain.
- A cohort of 886 men diagnosed with low-grade prostate cancer completed dietary assessments to evaluate their adherence to dietary guidelines and inflammatory potential.
- Results showed that after about 6.5 years, about 21% of participants experienced grade reclassification, indicating an ongoing need for research on dietary impacts on prostate cancer outcomes.
Gleason grade group (GG) is the most powerful prognostic variable in localized prostate cancer; however, interobserver variability remains a challenge. Artificial intelligence algorithms applied to histopathologic images standardize grading, but most have been tested only for agreement with pathologist GG, without assessment of performance with respect to oncologic outcomes. We compared deep learning-based and pathologist-based GGs for an association with metastatic outcome in three surgical cohorts comprising 777 unique patients.
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- Active surveillance (AS) is a safe and acceptable treatment strategy for men with low- and intermediate-risk prostate cancer, showing a high overall survival (OS) rate of 84.1% and metastasis-free survival (MFS) exceeding 99% over a follow-up period of more than 6 years.
- The study analyzed clinical data from nearly 27,000 men across 15 countries, revealing that while there was no significant change in overall survival rates over time, metastasis-free survival rates improved notably.
- Treatment changes were primarily driven by anxiety or tumor progression, with the most common radical treatment being surgery, which resulted in 90% of men remaining free from biochemical recurrence after 5 years.