Discovery of Undescribed Flavonoid and Rotenoid Derivatives from the Leaves of Derris trifoliata with Their Cytotoxic Activity.

Phytochemical study on the leaves of Derris trifoliata led to the isolation of five rotenoids (3-7) and ten flavonoid derivatives (1, 2, 8-15). Three of them, (2S)-5,7-dihydroxy-6-(2-hydroxyethyl)-2-(4-hydroxyphenyl)-8-(3-methylbut-2-en-1-yl)chroman-4-one (1), keampferol 3-O-[6-O-(E)-feruloyl-β-D-glucopyranosyl]-(1→2)-O-[α-L-rhamnopyranosyl-(1→6)-β-D-glucopyranoside (2), and (+)-13-homo-13-oxa-6a,12a-dehydrorotenone (3) were verified by Scifinder as previously undescribed compounds. Their chemical structures were elucidated by using IR, ECD, HR-ESI-MS, 1D and 2D NMR methods.

Pembrolizumab with or without bevacizumab in platinum-resistant recurrent or metastatic nasopharyngeal carcinoma: a randomised, open-label, phase 2 trial.

Background: Vascular endothelial growth factor (VEGF) is overexpressed in nasopharyngeal carcinoma and suppresses the anti-tumour immune response. Previous studies have shown that adding anti-VEGF treatment to PD-1 inhibition treatment strategies improves tumour response. We aimed to compare the efficacy of pembrolizumab, a PD-1 inhibitor, with or without bevacizumab, a VEGF inhibitor, in nasopharyngeal carcinoma.

Development and Evaluation of Non-Antibiotic Growth Promoters for Food Animals.

The widespread utilization of antibiotic growth promoters (AGPs) boosts the growth rate of food animals and enhances human living standards. Nevertheless, it is accompanied by escalating antibiotic resistance. Consequently, there is an urgent demand to develop novel alternatives to growth promoters.

In vitro and in silico anti-inflammatory effect of minor constituents from the roots of Buch.-Ham. ex D. Don.

Vietnamese traditional medicine has utilised the roots of Buch.-Ham. ex D.