Publications by authors named "B J Sheehan"
Article Synopsis
- vB_KquU_φKuK6 is a bacteriophage that infects multidrug-resistant bacterial strains and shows potential for phage therapy despite being a temperate phage.
- The phage's structure includes a complex capsid and a genome with genes essential for lytic and lysogenic infections, along with properties that indicate stability across various conditions.
- While vB_KquU_φKuK6 can reduce biofilm formation and enhance the effectiveness of certain antibiotics, it cannot be used directly for therapy due to its nature but could be valuable when modified or used alongside treatments.
The acetylation of autophagy protein 9 A (ATG9A) in the lumen of the endoplasmic reticulum (ER) by ATase1 and ATase2 regulates the induction of reticulophagy. Analysis of the ER-specific ATG9A interactome identified calreticulin (CALR), an ER luminal Ca-binding chaperone, as key for ATG9A activity. Specifically, if acetylated, ATG9A is sequestered by CALR and prevented from engaging FAM134B and SEC62.
View Article and Find Full Text PDFElectric vehicles (EVs) differ significantly from their internal combustion engine (ICE) counterparts, with reduced mechanical parts, Lithium-ion batteries and differences in pedal and transmission control. These differences in vehicle operation, coupled with the proliferation of EVs on our roads, warrant an in-depth investigation into the divergent risk profiles and driving behaviour of EVs, Hybrids (HYB) and ICEs. In this unique study, we analyze a novel telematics dataset of 14,642 vehicles in the Netherlands accompanied by accident claims data.
View Article and Find Full Text PDFHealth-related quality of life does not deteriorate while waiting for anterior cruciate reconstruction.
Knee Surg Sports Traumatol Arthrosc
November 2024
Purpose: The aim of this study was to determine how preoperative health-related quality of life (HRQoL) is affected by the duration of the wait time (WT) for anterior cruciate ligament reconstruction (ACLR) once a decision is made to proceed with surgery.
Methods: This was a multi-centre prospective cohort study. One hundred and twenty-two patients 14 years of age and above waiting for ACLR completed the International Knee Documentation Committee (IKDC) demographic, current health assessment and subjective knee evaluation (SKF) forms on the day of decision to operate and the day of surgery.