Case report: Complete response of recurrent locally advanced basal cell carcinoma following addition of vismodegib to neoadjuvant cemiplimab therapy.

Locally advanced basal cell carcinoma (laBCC) remains a significant management challenge. Historically, surgery or radiotherapy represented the major treatment options. Recently, hedgehog inhibitors and checkpoint inhibitors have demonstrated significant activity.

Self-Reported COVID-19 Vaccine Status and Barriers for Pediatric Emergency Patients and Caregivers.

Objective: This study determined if the caregivers of children in the emergency department (ED) have the same COVID-19 vaccination status as the child, the reasons they chose to not vaccinate the child, and self-identified barriers to vaccination to determine if the ED is appropriate for vaccination intervention.

Methods: A survey was administered to caregivers of pediatric ED patients at four Children's Hospitals in: Augusta, GA, Buffalo, NY, Madison, WI, and Sacramento, CA. Participants were asked about their and the child's demographics, vaccination status, and barriers to vaccination.

Dynamic proportional loss of functional connectivity revealed change of left superior frontal gyrus in subjective cognitive decline: an explanatory study based on Chinese and Western cohorts.

Brain network dynamics have been extensively explored in patients with subjective cognitive decline (SCD). However, these studies are susceptible to individual differences, scanning parameters, and other confounding factors. Therefore, how to reveal subtle SCD-related subtle changes remains unclear.

The Mediating Roles of Resilience and Flow in Linking Basic Psychological Needs to Tertiary EFL Learners' Engagement in the Informal Digital Learning of English: A Mixed-Methods Study.

Resilience and flow are crucial in language education, yet most research focuses on formal learning environments, with limited studies on their impact in informal settings. This study explores the relationship between basic psychological needs and engagement in the context of informal digital English learning (IDLE). Using a mixed-methods design, data were collected from 512 Chinese EFL learners.

Diagnostic and Prognostic Challenges of Oral Melanoma in Dogs: A Literature Review and 2 Case Studies.

Oral melanoma is the most common maxillofacial malignancy in dogs. A unique characteristic of melanoma is its ability to mimic other oral tumors, which makes it one of the most challenging oral tumors to diagnose, especially since 30% to 40% of cases are amelanotic. This article presents 2 case reports of dogs with amelanotic oral melanoma that were both diagnostically challenging.