Publications by authors named "B J Regueiro"
Background: The development of new large-scale saliva pooling detection strategies can significantly enhance testing capacity and frequency for asymptomatic individuals, which is crucial for containing SARS-CoV-2.
Objective: This study aims to implement and scale-up a SARS-CoV-2 screening method using pooled saliva samples to control the virus in critical areas and assess its effectiveness in detecting asymptomatic infections.
Methods: Between August 2020 and February 2022, our laboratory received a total of 928,357 samples.
Article Synopsis
- The study examines how social restrictions and different variants, specifically Alpha, Delta, and Omicron-BA.1, affected the spread of SARS-CoV-2 in Galicia, Spain.
- Using genomic data and mobility statistics, the research found that initial variant introductions mostly came from other Spanish regions and France, later shifting to include imports from Portugal and the U.S.
- Despite the number of introductions, most did not contribute significantly to the pandemic's evolution in Galicia, but major coastal cities were identified as key areas for viral transmission.
Article Synopsis
- The study investigates how social restrictions and different variants, specifically Alpha, Delta, and Omicron, affected SARS-CoV-2 transmission in Galicia, Spain.
- Using genomic data and mobility information, the research shows that the Alpha variant initially spread from other Spanish regions and France, while later variants saw increased influences from Portugal and the USA.
- Key coastal cities in Galicia were identified as significant hubs for the virus's dissemination, underscoring the importance of regional connectivity for public health strategies.
Background: Early life determinants of the development of gut microbiome composition in infants have been widely investigated; however, if early life pollutant exposures, such as tobacco or mercury, have a persistent influence on the gut microbial community, its stabilization at later childhood remains largely unknown.
Objective: In this exposome-wide study, we aimed at identifying the contribution of exposure to tobacco and mercury from the prenatal period to childhood, to individual differences in the fecal microbiome composition of 7-year-old children, considering co-exposure to a width of established lifestyle and clinical determinants.
Methods: Gut microbiome was studied by 16S rRNA amplicon sequencing in 151 children at the genus level.
The Modification of the Illumina CovidSeq™ Workflow for RSV Genomic Surveillance: The Genetic Variability of RSV during the 2022-2023 Season in Northwest Spain.
Int J Mol Sci
November 2023
Article Synopsis
- There is an increasing focus on tracking the Respiratory Syncytial Virus (RSV) for emerging mutations that may affect the effectiveness of antiviral treatments.
- A new scalable protocol for enhancing viral nucleic acid analysis has been developed based on the Illumina CovidSeq workflow, successfully sequencing numerous RSV genomes.
- This method achieved significant coverage of key viral genes and identified mutations linked to reduced treatment efficacy, aiding in timely detection and response to potential RSV mutations.