Publications by authors named "B J O'Leary"
Purpose: While treatment modalities for Maisonneuve fractures involving the proximal third of the fibula are established, no studies to date have reported outcomes associated with syndesmotic-only fixation of middle third fibular shaft fractures. The purpose of this study was to evaluate outcomes associated with syndesmotic-only fixation in the treatment of Maisonneuve fractures involving the middle third of the fibula.
Methods: A retrospective review was conducted on 257 cases of syndesmotic ankle instability with associated fibular fractures at a level 1 trauma center between 2013 and 2023.
Background And Aims: Femoral artery access is widely used despite recent increase in radial access for percutaneous coronary interventions (PCI). Femoral artery closure devices are used to shorten vascular closure time and reduce bleeding. We sought to examine sex-based outcomes of femoral artery vascular closure devices (VCD) in patients undergoing PCI.
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- - The prevalence of brownfields with unknown chemical contaminants necessitates quick and cost-effective exposure reduction methods, especially in industrial cities like Detroit where harmful volatile organic compounds (VOCs) are commonly found.
- - Phytoscreening, which analyzes plant tissues to detect belowground contamination, offers a promising alternative to traditional methods that involve screening soil and groundwater, yet few studies have directly compared these approaches.
- - Research comparing concentrations of six VOCs in plant tissues and conventional media at two Detroit brownfield sites found that plants often showed similar or higher VOC levels, particularly in leaves and roots, suggesting phytoscreening could be a reliable method for detecting contamination.
The co-occurrence of germline and somatic oncogenic alterations is frequently observed in breast cancer, but their combined biologic and clinical significance has not been evaluated. To assess the role of germline-somatic interactions on outcomes in routine practice, we developed an integrated clinicogenomic pipeline to analyze the genomes of over 4,500 patients with breast cancer. We find that germline (g) -associated tumors are enriched for loss-of-function mutations and manifest poor outcomes on standard-of-care, front-line CDK4/6 inhibitor (CDK4/6i) combinations.
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