Publications by authors named "B J Leader"
Obstructive Sleep Apnea (OSA) is a common sleep-related breathing disorder characterized by airway obstruction during sleep. Diagnosing pediatric OSA is challenging, particularly in underrepresented populations, leading to disparities in treatment and long-term negative health outcomes. Our study aimed to identify alternative diagnostic tools by investigating genome-wide epigenetic changes and associated transcriptomic alterations in Black female, pediatric patients with OSA.
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- The study investigates the effectiveness of rapid diagnostic tests (RDTs) in detecting N-antigen levels and viral load in various specimen types among individuals exposed to confirmed COVID-19 cases.
- The results show that antigen concentration correlates with viral load within the same specimen type but differs across types, with symptomatic individuals showing higher antigen levels.
- Saliva samples had lower antigen concentrations than nasal swabs, suggesting that saliva-based RDTs need enhanced sensitivity to match the performance of nasal tests.
Objective: To determine the effects of sperm deoxyribonucleic acid (DNA) fragmentation at the time of fertilization on in vitro fertilization (IVF) outcomes and genetic diagnosis using next generation sequencing.
Design: Prospective double-blinded study.
Setting: Private Clinic.
Lagophthalmos after rhinoplasty- a possible complication.
J Plast Reconstr Aesthet Surg
October 2022
Screening for Severe Acute Respiratory Syndrome Coronavirus 2 in Close Contacts of Individuals With Confirmed Infection: Performance and Operational Considerations.
J Infect Dis
December 2022
Background: Point-of-care and decentralized testing for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is critical to inform public health responses. Performance evaluations in priority use cases such as contact tracing can highlight trade-offs in test selection and testing strategies.
Methods: A prospective diagnostic accuracy study was conducted among close contacts of coronavirus disease 2019 (COVID-19) cases in Brazil.