Publications by authors named "B J Knoll"
Injuries to the nervous system lead to irreversible damage and limited functional recovery. The peripheral nervous system (PNS) can self-regenerate to some extent for short nerve gaps. In contrast, the central nervous system (CNS) has an intrinsic limitation to self-repair owing to its convoluted neural microenvironment and inhibitory response.
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- Peripheral nerve injuries can lead to the formation of neuromas, which are abnormal growths at the injury site that can stop nerves from healing properly.
- Researchers studied human neuroma tissue and compared it to healthy nerves from the same person to understand what happens at the injury site over time (1-13 months after injury).
- They found that even though the nerve repair cells called Schwann cells were present, they were in a "repair mode" and different from healthy cells, with signs of inflammation and reduced ability to form myelin, which is important for nerve function.
Article Synopsis
- - Synaptic dysfunction plays a crucial role in SHANK-associated disorders like autism, schizophrenia, and Phelan-McDermid syndrome, but understanding its effects on synaptic structure is limited.
- - The study used advanced imaging techniques (expansion and STED microscopy) to examine the synaptic nanostructures in both human and mouse brain tissues, focusing on SHANK3-KO mice.
- - Findings revealed unique shape profiles of murine postsynaptic scaffolds and significant changes in the organization of synaptic domains due to SHANK3 deficiency, shedding light on the molecular mechanisms of synaptic dysfunction in neuropsychiatric disorders.
Purpose: The aim of the present study was to investigate whether term infants with feeding difficulties who received either a 5-minute premature infant oral motor intervention (PIOMI) or a 15-minute Fucile treatment had different outcomes, compared to term infants in a nontreatment group.
Method: Stable term infants ( = 51) born between 37-41 weeks of gestational age with feeding difficulties were randomly assigned into one of two intervention groups and a control group. One intervention group received PIOMI and the other group received Fucile treatment once a day for seven consecutive days; the control group received usual care only.