Symptom networks of common mental disorders in public versus private healthcare settings in India.

We present a series of network analyses aiming to uncover the symptom constellations of depression, anxiety and somatization among 2,796 adult primary health care attendees in Goa, India, a low- and middle-income country (LMIC). Depression and anxiety are the leading neuropsychiatric causes of disability. Yet, the diagnostic boundaries and the characteristics of their dynamically intertwined symptom constellations remain obscure, particularly in non-Western settings.

A Confirmatory Factory Analysis of the Exercise Sensitivity Questionnaire (ESQ).

Purpose: The Exercise Sensitivity Questionnaire (ESQ) is a self-report measure used to assess the extent to which different physical sensations of exercise elicit anxiety (ie, exercise sensitivity). The ESQ was developed for individuals with cardiovascular conditions and initially validated in a non-clinical sample. This study evaluates the factor structure and measurement invariance in a clinical sample of adults with various cardiovascular conditions.

CD21 B cells reveal a unique glycosylation pattern with hypersialylation and hyperfucosylation.

Background: The posttranslational modification of cellular macromolecules by glycosylation is considered to contribute to disease pathogenesis in autoimmune and inflammatory conditions. In a subgroup of patients with common variable immunodeficiency (CVID), the occurrence of such complications is associated with an expansion of naïve-like CD21 B cells during a chronic type 1 immune activation. The glycosylation pattern of B cells in CVID patients has not been addressed to date.

Adaptive Chest Cavity Expansion Following Lung Allograft Oversizing in Idiopathic Pulmonary Fibrosis.

Introduction: Due to parenchymal fibrosis and chest wall contraction in idiopathic pulmonary fibrosis (IPF), donor lung allografts are generally undersized to accommodate smaller diseased chest cavities. We hypothesized that transplanting oversized allografts (OAs) in recipients with IPF would be associated with thoracic cavity expansion.

Methods: A single center retrospective study of IPF patients who underwent lung transplant between 2014 and 2022 was conducted.

The Wheat NLR Protein PM3b Localises to Endoplasmic Reticulum-Plasma Membrane Contact Sites and Interacts With AVRPM3 Through Its LRR Domain.

Plant nucleotide-binding leucine-rich repeat (NLR) proteins are intracellular immune receptors that directly or indirectly perceive pathogen-derived effector proteins to induce an immune response. NLRs display diverse subcellular localisations, which are associated with the capacity of the immune receptor to confer disease resistance and recognise its corresponding avirulence effector. In wheat, the NLR PM3b recognises the wheat powdery mildew effector AVRPM3 and we examined the molecular mechanism underlying this recognition.