Efficacy and safety of elobixibat in patients with chronic constipation-A randomized, multicenter, double-blind, placebo-controlled, parallel-group study from India.

Background: Elobixibat is a locally acting ileal bile acid transporter (IBAT) inhibitor that relieves functional constipation in patients by accelerating colonic transit. In this study, we aimed at determining the efficacy and safety of elobixibat for short-term treatment (two weeks) of chronic constipation in Indian patients.

Methods: The present study was a randomized, double-blind, parallel-group, placebo-controlled, phase III study to evaluate efficacy and safety of elobixibat.

A fuzzy based computational model to analyze the influence of mitochondria, buffer, and ER fluxes on cytosolic calcium distribution in neuron cells.

A free calcium ion in the cytosol is essential for many physiological and physical functions. Also, it is known as a second messenger as the quantity of free calcium ions is an essential part of brain signaling. In this work, we have attempted to study calcium signaling in the presence of mitochondria, buffer, and endoplasmic reticulum fluxes.

Butterfly Diagram and Other Properties of Plage Areas from Kodaikanal Ca ii K Photographs Covering 1904 - 2007.

Ca ii K observations of the Sun have a great potential for probing the Sun's magnetism and activity, as well as for reconstructing solar irradiance. The Kodaikanal Solar Observatory (KoSO) in India, houses one of the most prominent Ca ii K archives, spanning from 1904 to 2007, obtained under the same experimental conditions over a century, a feat very few other sites have achieved. However, the KoSO Ca ii K archive suffers from several inconsistencies (e.

Treatment of Pediatric Acute Lymphoblastic Leukemia in India as per modified BFM 95 protocol with Minimal Residual Disease monitoring.

Survival outcomes of Pediatric Acute Lymphoblastic Leukemia (ALL) in the developing world have lagged. Here we report improved outcomes of pediatric ALL from India. We analyzed outcomes of children with ALL treated at our center between 2016 and 2021.

JAK2 p.R564 germ line variants associated with hereditary thrombocythemia and hematologic neoplasms.

The Janus kinase 2 (JAK2) V617F mutation activates the transcription pathway and has been well-characterized as a driver of myeloproliferative neoplasms (MPNs). Recently, there has been a heightened interest in understanding germline predisposition to hematological malignancies including MPN, including several reports of familial MPN. Here, we retrospectively analyzed medical records and data from genetic testing to describe twelve patients with germline variants at amino acid position 564 of JAK2.